ArticleDisease markers2014
Apolipoprotein E gene polymorphism and serum lipid profile in Saudi patients with psoriasis.
Article in Disease markers, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 29 citations in OpenAlex.
- Association Between Psoriasis and Dementia: Current Evidence.Frontiers in aging neuroscience · 2020Pooled it
- Cognitive Decline and Neurodegenerative Markers in Psoriasis: The Role of APOE4 and Beta-Amyloid.Dermatology practical & conceptual · 2026Article
- A Transcriptomic Atlas of Healthy Human Skin Links Regional Identity to Inflammatory Disease.bioRxiv : the preprint server for biology · 2025Article
- Relationship between uncoupling protein 1 (UCP1) levels and psoriasis.Turkish journal of medical sciences · 2025Article
- The relationship between blood lipid and risk of psoriasis: univariable and multivariable Mendelian randomization analysis.Frontiers in immunology · 2023Article
- Literature Overview of the Relation Between Psoriasis and Alzheimer.Neuropsychiatric disease and treatment · 2023Review
- Psoriasis: An Immunogenetic Perspective.Global medical genetics · 2022Review
- No increased risk of Alzheimer's disease among people with immune-mediated inflammatory diseases: findings from a longitudinal cohort study of U.S. older adults.BMC rheumatology · 2021Article
- Analysis of the Potential Genetic Links between Psoriasis and Cardiovascular Risk Factors.International journal of molecular sciences · 2021Review
- The Relationship Between Alzheimer's Disease and Skin Diseases: A Review.Clinical, cosmetic and investigational dermatology · 2021Review
- Article
- Synergism between apolipoprotein E Ɛ4 allele and paraoxonase (PON1) 55-M allele is associated with risk of systemic lupus erythematosus.Clinical rheumatology · 2018Article
- The Protein Tyrosine Phosphatase Nonreceptor 22 (Clinical medicine insights. Arthritis and musculoskeletal disorders · 2018Article
- Article
- Article
- Apolipoprotein E Gene Polymorphisms in Saudi Patients with Systemic Lupus Erythematosus.Clinical medicine insights. Arthritis and musculoskeletal disorders · 2016Article
- Genetic association of apolipoprotein E polymorphisms with inflammatory bowel disease.World journal of gastroenterology · 2015Article
- Apolipoprotein E Gene Polymorphism, Serum Lipids, and Risk of Superficial Fungal Infections in Egyptian Patients - A Preliminary Case-Controlled Study.Indian journal of dermatologyArticle
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND/
aimApolipoprotein E (APOE) gene variants have been reported to influence psoriasis risk. However, data is limited to a few ethnicities and no similar study has been performed in middle eastern populations. We investigated this association in Saudi psoriasis patients.
methodsSaudi subjects (294) were genotyped for APOE gene using APOE StripAssay kit.
resultsThe frequencies of alleles ε2, ε4, and genotypes ε3/ε4 and ε3/ε2 were significantly higher in psoriasis patients compared with those in controls. The frequency of ε3 allele and ε3/ε3 genotype was significantly lower in patients. Other genotypes, ε2/ε4, ε2/ε2, and ε4/ε4, were absent in both groups. The serum cholesterol, triglycerides, and LDL levels were significantly higher in psoriasis patients contrary to HDL level. Patients with APOE ε 4 had significantly higher levels of total cholesterol and LDL cholesterol, whereas those with the ε2 had higher HDL cholesterol, and triglycerides.
conclusionAPOE alleles ε2, ε4, and genotypes ε2/ε3 and ε4/ε3 are associated with psoriasis and can be a risk factor while allele ε3 and genotype ε3/ε3 may be protective for psoriasis in Saudis. Results of lipid profile support that psoriasis is one of the independent risk factors for hyperlipidemia and emphasize the need of screening cardiovascular diseases in psoriatic patients.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.