ArticleScience signaling2014
Mucus, it is not just a static barrier.
Article in Science signaling, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed.
- Alterations in intestinal development and barrier function in response to dietary β-mannanase in growing broilers.Frontiers in veterinary science · 2026Article
- Ginsenoside Rk2, a dehydroprotopanaxadiol saponin, alleviates alcoholic liver disease via regulating NLRP3 and NLRP6 inflammasome signaling pathways in mice.Journal of pharmaceutical analysis · 2023Article
- Autophagy and the Insulin-like Growth Factor (IGF) System in Colonic Cells: Implications for Colorectal Neoplasia.International journal of molecular sciences · 2023Review
- The relationship between intestinal goblet cells and the immune response.Bioscience reports · 2020Review
- Different Forms of TFF3 in the Human Saliva: Heterodimerization with IgG Fc Binding Protein (FCGBP).International journal of molecular sciences · 2019Article
- Control and dysregulation of redox signalling in the gastrointestinal tract.Nature reviews. Gastroenterology & hepatology · 2019Review
- Enhancement of Mucus Production in Eukaryotic Cells and Quantification of Adherent Mucus by ELISA.Bio-protocol · 2018Article
- Identification of a novel interaction between corticotropin releasing hormone (Crh) and macroautophagy.Scientific reports · 2016Article
- The Goldilocks Conundrum: NLR Inflammasome Modulation of Gastrointestinal Inflammation during Inflammatory Bowel Disease.Critical reviews in immunology · 2016Review
- Intestinal Autophagy and Its Pharmacological Control in Inflammatory Bowel Disease.Frontiers in immunology · 2016Review
- Links of Autophagy Dysfunction to Inflammatory Bowel Disease Onset.Digestive diseases (Basel, Switzerland) · 2016Review
- TFF Peptides Play a Role in the Immune Response Following Oral Infection of Mice with Toxoplasma Gondii.European journal of microbiology & immunology · 2015Article
Corrections and comments
- Comment on
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The mucus layer is an important component of host defense against microbial infection of the intestinal epithelium. Autophagy is required for secretion of mucus by intestinal goblet cells. However, the upstream pathways that activate autophagy in this context are not yet fully elucidated. A recent study by Wlodarska et al. shows that NLRP6, a member of the Nod-like receptor family of pattern-recognition receptors, and the inflammasome pathway promote autophagy-dependent mucus secretion from goblet cells, providing a potential mechanism by which inflammasomes maintain intestinal homeostasis.
Indexed as
Identifiers
24782564What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.