ArticleBMJ (Clinical research ed.)2014
Relation of physical activity time to incident disability in community dwelling adults with or at risk of knee arthritis: prospective cohort study.
Article in BMJ (Clinical research ed.), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 74 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
74 citing papers in PubMed, 3 syntheses or guidelines pooled it, 169 citations in OpenAlex.
- Effect of high-intensity training on improving knee flexion strength and quality of life in patients with knee osteoarthritis: a systematic review and meta-analysis of randomized controlled trials.Frontiers in physiology · 2025Pooled it
- The Association of Objectively Measured Physical Activity and Sedentary Behavior with (Instrumental) Activities of Daily Living in Community-Dwelling Older Adults: A Systematic Review.Clinical interventions in aging · 2021Pooled it
- Behavioural physical activity interventions in participants with lower-limb osteoarthritis: a systematic review with meta-analysis.BMJ open · 2015Pooled it
- Functional Capacity at Rehabilitation Discharge Predicts Physical Activity Characteristics 24 Weeks Later for People With Total Knee Arthroplasty: A Secondary Analysis of a Randomized Controlled Trial.Archives of physical medicine and rehabilitation · 2025Trial
- Bringing the Walk with Ease Programme to the UK: a mixed-methods study to assess the relevance, acceptability, and feasibility of implementation for people with arthritis and musculoskeletal conditions.Translational behavioral medicine · 2023Trial
- Physical activity and sedentary behavior in breast cancer survivors: New insight into activity patterns and potential intervention targets.Gynecologic oncology · 2015Trial
- Weight loss and physical activity after total knee replacement: Study protocol for the Healthy Living randomized controlled trial.Osteoarthritis and cartilage open · 2026Article
- The potential of unstructured "physical activity" data for understanding relationships between movement-induced joint loading and osteoarthritis progression.Osteoarthritis and cartilage open · 2026Article
- Gluteus Maximus-gastrocnemius versus Quadriceps Biofeedback Neuromuscular Training during Gait in Knee Osteoarthritis: Development and Feasibility of a Novel Concept with a Pilot Study.Journal of medical signals and sensors · 2026Article
- Longitudinal Effects of Snow-season Activity Decline on Physical Function in Older Adults in Rural Snowy Regions.Physical therapy research · 2026Article
- Article
- Association of the interaction between daily step counts and frailty with disability in older adults.GeroScience · 2025Article
- KArAT (Knee Arthroplasty Activity Trial): Rationale and design features of a multicenter randomized controlled trial.Osteoarthritis and cartilage open · 2025Article
- A Catalog of "Knee Friendly" Aerobic Exercises Developed for Patients With Knee Osteoarthritis: An International Patient Survey.ACR open rheumatology · 2025Article
- Association Between Depressive Symptoms and Self-Reported Physical Activity in Persons With Knee Osteoarthritis.The Journal of rheumatology · 2025Article
- Is a higher body mass index associated with longer duration of survival with disability in frail than in non-frail older adults?International journal of obesity (2005) · 2025Article
- A Remotely Delivered Light-Intensity Physical Activity Intervention for Older Cancer Survivors: Protocol for a Feasibility Randomized Controlled Trial.JMIR research protocols · 2024Article
- The current insights of mitochondrial hormesis in the occurrence and treatment of bone and cartilage degeneration.Biological research · 2024Review
- Minimal amount of exercise prevents incident dementia in cognitively normal older adults with osteoarthritis: a retrospective longitudinal follow-up study.Scientific reports · 2023Article
- Accelerometer-measured sedentary behavior and risk of functional disability in older Japanese adults: a 9-year prospective cohort study.The international journal of behavioral nutrition and physical activity · 2023Article
14 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
12 authors at 7 institutions in 1 country.
Funding
Abstract
objectiveTo investigate whether objectively measured time spent in light intensity physical activity is related to incident disability and to disability progression.
designProspective multisite cohort study from September 2008 to December 2012.
settingBaltimore, Maryland; Columbus, Ohio; Pittsburgh, Pennsylvania; and Pawtucket, Rhode Island, USA.
participantsDisability onset cohort of 1680 community dwelling adults aged 49 years or older with knee osteoarthritis or risk factors for knee osteoarthritis; the disability progression cohort included 1814 adults.
main outcome measuresPhysical activity was measured by accelerometer monitoring. Disability was ascertained from limitations in instrumental and basic activities of daily living at baseline and two years. The primary outcome was incident disability. The secondary outcome was progression of disability defined by a more severe level (no limitations, limitations to instrumental activities only, 1-2 basic activities, or ≥3 basic activities) at two years compared with baseline.
resultsGreater time spent in light intensity activities had a significant inverse association with incident disability. Less incident disability and less disability progression were each significantly related to increasing quartile categories of daily time spent in light intensity physical activities (hazard ratios for disability onset 1.00, 0.62, 0.47, and 0.58, P for trend=0.007; hazard ratios for progression 1.00, 0.59, 0.50, and 0.53, P for trend=0.003) with control for socioeconomic factors (age, sex, race/ethnicity, education, income) and health factors (comorbidities, depressive symptoms, obesity, smoking, lower extremity pain and function, and knee assessments: osteoarthritis severity, pain, symptoms, prior injury). This finding was independent of time spent in moderate-vigorous activities.
conclusionThese prospective data showed an association between greater daily time spent in light intensity physical activities and reduced risk of onset and progression of disability in adults with osteoarthritis of the knee or risk factors for knee osteoarthritis. An increase in daily physical activity time may reduce the risk of disability, even if the intensity of that additional activity is not increased.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.