ArticleMolecular biology and evolution2014
Expression evolution facilitated the convergent neofunctionalization of a sodium channel gene.
Article in Molecular biology and evolution, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 32 citations in OpenAlex.
- The genetic foundations of convergent traits.Nature reviews. Genetics · 2026Review
- Evolutionary causes and consequences of gene duplication.Nature reviews. Genetics · 2026Review
- Differential expression of steroid-related genes across electrosensory brain regions in two sexually dimorphic species of electric knifefish.General and comparative endocrinology · 2024Review
- Ecologically mediated differences in electric organ discharge drive evolution in a sodium channel gene in South American electric fishes.Biology letters · 2024Article
- Evolution of androgen receptors contributes to species variation in androgenic regulation of communication signals in electric fishes.Molecular and cellular endocrinology · 2023Article
- Studying convergent evolution to relate genotype to behavioral phenotype.The Journal of experimental biology · 2020Review
- From phenotype to genotype: the precursor hypothesis predicts genetic influences that facilitate transitions in social behavior.Current opinion in insect science · 2019Review
- Comparative Transcriptome Analyses Reveal the Role of Conserved Function in Electric Organ Convergence Across Electric Fishes.Frontiers in genetics · 2019Article
- Rapid evolution of a voltage-gated sodium channel gene in a lineage of electric fish leads to a persistent sodium current.PLoS biology · 2018Article
- Electric organ discharge diversification in mormyrid weakly electric fish is associated with differential expression of voltage-gated ion channel genes.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2017Article
- Daily rhythmicity of clock gene transcript levels in fast and slow muscle fibers from Chinese perch (Siniperca chuatsi).BMC genomics · 2016Article
- Towards Consensus Gene Ages.Genome biology and evolution · 2016Article
- Purifying selection acts on coding and non-coding sequences of paralogous genes in Arabidopsis thaliana.BMC genomics · 2016Article
- Site-directed mutagenesis, in vivo electroporation and mass spectrometry in search for determinants of the subcellular targeting of Rab7b paralogue in the model eukaryote Paramecium octaurelia.European journal of histochemistry : EJH · 2016Article
- Complex Homology and the Evolution of Nervous Systems.Trends in ecology & evolution · 2016Review
- Compensatory Drift and the Evolutionary Dynamics of Dosage-Sensitive Duplicate Genes.Genetics · 2016Article
- Article
- Evolutionary Fate of the Androgen Receptor-Signaling Pathway in Ray-Finned Fishes with a Special Focus on Cichlids.G3 (Bethesda, Md.) · 2015Article
- Neofunctionalization of a duplicate hatching enzyme gene during the evolution of teleost fishes.BMC evolutionary biology · 2014Article
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Authors and funding
4 authors at 2 institutions in 1 country.
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Abstract
Ion channels have played a substantial role in the evolution of novel traits across all of the domains of life. A fascinating example of a novel adaptation is the convergent evolution of electric organs in the Mormyroid and Gymnotiform electric fishes. The regulated currents that flow through ion channels directly generate the electrical signals which have evolved in these fish. Here, we investigated how the expression evolution of two sodium channel paralogs (Scn4aa and Scn4ab) influenced their convergent molecular evolution following the teleost-specific whole-genome duplication. We developed a reliable assay to accurately measure the expression stoichiometry of these genes and used this technique to analyze relative expression of the duplicate genes in a phylogenetic context. We found that before a major shift in expression from skeletal muscle and neofunctionalization in the muscle-derived electric organ, Scn4aa was first downregulated in the ancestors of both electric lineages. This indicates that underlying the convergent evolution of this gene, there was a greater propensity toward neofunctionalization due to its decreased expression relative to its paralog Scn4ab. We investigated another derived muscle tissue, the sonic organ of Porichthys notatus, and show that, as in the electric fishes, Scn4aa again shows a radical shift in expression away from the ancestral muscle cells into the evolutionarily novel muscle-derived tissue. This study presents evidence that expression downregulation facilitates neofunctionalization after gene duplication, a pattern that may often set the stage for novel trait evolution after gene duplication.
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