ArticleThe Journal of comparative neurology2014
Diversity and wiring variability of visual local neurons in the Drosophila medulla M6 stratum.
Article in The Journal of comparative neurology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 23 citations in OpenAlex.
- Article
- Two distinct mechanisms of Plexin A function in Drosophila optic lobe lamination and morphogenesis.Development (Cambridge, England) · 2024Article
- Neuronal "parts list" and wiring diagram for a visual system.bioRxiv : the preprint server for biology · 2024Article
- Synaptic targets of photoreceptors specialized to detect color and skylight polarization ineLife · 2021Article
- Comprehensive map of visual projection neurons for processing ultraviolet information in the Drosophila brain.The Journal of comparative neurology · 2021Article
- Bitbow Enables Highly Efficient Neuronal Lineage Tracing and Morphology Reconstruction in SingleFrontiers in neural circuits · 2021Article
- Article
- Site-Specific Recombination with Inverted Target Sites: A Cautionary Tale of Dicentric and Acentric Chromosomes.Genetics · 2020Article
- Cellular and synaptic adaptations of neural circuits processing skylight polarization in the fly.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2020Article
- Retinal perception and ecological significance of color vision in insects.Current opinion in insect science · 2017Review
- From the Eye to the Brain: Development of the Drosophila Visual System.Current topics in developmental biology · 2016Review
- Optimized tools for multicolor stochastic labeling reveal diverse stereotyped cell arrangements in the fly visual system.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Versatile genetic paintbrushes: Brainbow technologies.Wiley interdisciplinary reviews. Developmental biologyReview
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Authors and funding
5 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Local neurons in the vertebrate retina are instrumental in transforming visual inputs to extract contrast, motion, and color information and in shaping bipolar-to-ganglion cell transmission to the brain. In Drosophila, UV vision is represented by R7 inner photoreceptor neurons that project to the medulla M6 stratum, with relatively little known of this downstream substrate. Here, using R7 terminals as references, we generated a 3D volume model of the M6 stratum, which revealed a retinotopic map for UV representations. Using this volume model as a common 3D framework, we compiled and analyzed the spatial distributions of more than 200 single M6-specific local neurons (M6-LNs). Based on the segregation of putative dendrites and axons, these local neurons were classified into two families, directional and nondirectional. Neurotransmitter immunostaining suggested a signal routing model in which some visual information is relayed by directional M6-LNs from the anterior to the posterior M6 and all visual information is inhibited by a diverse population of nondirectional M6-LNs covering the entire M6 stratum. Our findings suggest that the Drosophila medulla M6 stratum contains diverse LNs that form repeating functional modules similar to those found in the vertebrate inner plexiform layer.
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