Trial reportInvestigative ophthalmology & visual science2014
Baseline visual field findings in the Idiopathic Intracranial Hypertension Treatment Trial (IIHTT).
Trial report in Investigative ophthalmology & visual science, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 24 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Multicenter, Double-blind, Randomized, Placebo-controlled Study of Weight-Reduction and/or Low Sodium Diet Plus Acetazolamide vs Diet Plus Placebo in Subjects With Idiopathic Intracranial Hypertension With Mild Visual Loss
Evolution of Body Mass Index in Idiopathic Intracranial Hypertension and Its Relationship With the Response to Treatment. Retrospective and Prospective Study
Who cites it
24 citing papers in PubMed, 2 syntheses or guidelines pooled it, 67 citations in OpenAlex.
- A systematic review of surgical treatments of idiopathic intracranial hypertension (IIH).Neurosurgical review · 2021Pooled it
- European headache federation guideline on idiopathic intracranial hypertension.The journal of headache and pain · 2018Guideline
- The effect of CSF drain on the optic nerve in idiopathic intracranial hypertension.The journal of headache and pain · 2019Trial
- Peripapillary Retinal Pigment Epithelium Layer Shape Changes From Acetazolamide Treatment in the Idiopathic Intracranial Hypertension Treatment Trial.Investigative ophthalmology & visual science · 2017Trial
- Visual Field Outcomes for the Idiopathic Intracranial Hypertension Treatment Trial (IIHTT).Investigative ophthalmology & visual science · 2016Trial
- Diagnostic Utility of Paton's Folds and Quantitative OCT Metrics in Pediatric Papilledema.Ophthalmology · 2026Article
- Surgical Interventions in Idiopathic Intracranial Hypertension-A Comprehensive Multi-Center Study of Outcome and the Role of Treatment Indication.European journal of neurology · 2026Observational
- Longitudinal visual outcomes in idiopathic intracranial hypertension: the role of early prognostic indicators and risk stratification in disease management.Journal of neurology · 2025Article
- Idiopathic intracranial hypertension in Asians: a retrospective dual-center study.The journal of headache and pain · 2024Article
- Idiopathic intracranial hypertension in two twin sisters.BMJ case reports · 2024Article
- Archetypal analysis of longitudinal visual fields for idiopathic intracranial hypertension patients presenting in a clinic setting.PLOS digital health · 2023Article
- Unsupervised Machine Learning Identifies Quantifiable Patterns of Visual Field Loss in Idiopathic Intracranial Hypertension.Translational vision science & technology · 2021Article
- Unilateral Optic Nerve Sheath Fenestration in Idiopathic Intracranial Hypertension: A 6-Month Follow-Up Study on Visual Outcome and Prognostic Markers.Life (Basel, Switzerland) · 2021Article
- Diagnosis and treatment of idiopathic intracranial hypertension.Cephalalgia : an international journal of headache · 2021Review
- Vision Loss in Optic Disc Drusen Correlates With Increased Macular Vessel Diameter and Flux and Reduced Peripapillary Vascular Density.American journal of ophthalmology · 2020Article
- Update on the Diagnosis and Treatment of Idiopathic Intracranial Hypertension.Seminars in neurology · 2019Review
- Genetic Survey of Adult-Onset Idiopathic Intracranial Hypertension.Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society · 2019Article
- Current concepts and strategies in the diagnosis and management of idiopathic intracranial hypertension in adults.Journal of neurology · 2017Review
- Update on Idiopathic Intracranial Hypertension.Neurologic clinics · 2017Review
- Elevated intracranial pressure causes optic nerve and retinal ganglion cell degeneration in mice.Experimental eye research · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo characterize visual field (VF) loss at the baseline visit and to evaluate VF quality control (QC) procedures in the Idiopathic Intracranial Hypertension Treatment Trial (IIHTT).
methodsThe Visual Field Reading Center (VFRC) evaluated 660 baseline VFs (1320 hemifields) from 165 enrolled patients. Three readers independently classified each superior and inferior hemifield and identified any abnormalities. A subset (20%) of the hemifields was reread to evaluate within- and between-reader agreements. The QC system addressed test parameters, patient data, and shipment errors.
resultsThe majority (60%) of the baseline hemifields consisted of localized nerve fiber bundle-type VF loss. Approximately one-third (31.5%) of all the classifications consisted of partial arcuate defects combined with an enlarged blind spot, making this the most common type of hemifield classification. Inferior hemifield loss was greater than superior loss for both study and nonstudy eyes. Reader agreements were >90% for both inferior and superior hemifields for two out of three readers. Test-retest reliability agreement for individual readers was 95% for both hemifields. There were few QC errors with only 5.48 error points per 100-point VF.
conclusionsThe most common type of IIHTT baseline hemifield abnormality was a localized nerve fiber bundle-like defect. Localized inferior hemifield loss was more common than superior hemifield loss. Quality control and within- and between-reader agreement were excellent for the IIHTT (ClinicalTrials.gov number, NCT01003639).
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.