Evidence map›Paper›PMID 24781891›Full record

Trial reportMedicine and science in sports and exercise2015

Reliability of maximal cardiopulmonary exercise testing in men with prostate cancer.

Jessica M Scott, Whitney E Hornsby, Amy Lane, Aarti A Kenjale, Neil D Eves, Lee W Jones

Open access · greenAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Medicine and science in sports and exercise, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
4.4field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it, 20 citations in OpenAlex.

  1. Efficacy of Exercise Therapy on Cardiorespiratory Fitness in Patients With Cancer: A Systematic Review and Meta-Analysis.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2018
    Pooled it
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  11. The Siconolfi step test: a valid and reliable assessment of cardiopulmonary fitness in older men with prostate cancer.European review of aging and physical activity : official journal of the European Group for Research into Elderly and Physical Activity · 2019
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 2 countries.

Jessica M Scott1Universities Space Research Association, Houston, TX; 2Duke University Medical Center, Durham, NC; 3Centre for Heart, Lung and Vascular Health, School of Health and Exercise Sciences, University of British Columbia, Kelowna, British Columbia, CANADA; and 4Cardiology Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY.
Whitney E Hornsby
Amy Lane
Aarti A Kenjale
Neil D Eves
Lee W Jones
Duke Medical Center · USMemorial Sloan Kettering Cancer Center · USUniversities Space Research Association · USUniversity of British Columbia · CA

Funding

Exercise Training, Erectile Dysfunction, and Prostate CancerR21CA133895 · NCI · DUKE UNIVERSITY · PI JONES, LEE W · 2009 to 2011
$503k
NCI NIH HHS R21 CA133895NCI NIH HHS R21-CA133895
6 · The paper itself

Abstract

purposeTo accurately assess exercise interventions and to evaluate acute and chronic cardiovascular effects in patients with early-stage cancer, consistently reliable functional outcome measures must be obtained. An incremental cardiopulmonary exercise test (CPET) with gas exchange measurement to assess peak oxygen consumption (V˙O2peak) provides the gold standard outcome of cardiorespiratory fitness.

methodsIn the context of a randomized controlled trial, 40 patients with prostate cancer (mean age, 59 ± 7 yr) after radical prostatectomy performed two maximal CPET within 5.6 ± 5.5 d of each other. Incremental treadmill tests were performed in the morning under identical laboratory conditions. Reliability and within-subject variability from test 1 to test 2 for peak and submaximal variables were assessed by correlation coefficients, intraclass correlations (ICC), Bland-Altman plots, coefficient of variation, and paired t-tests.

resultsThere was high reliability between CPET for V˙O2peak (r = 0.92; P < 0.001; ICC, 0.900), ventilatory threshold (r = 0.88; P < 0.001; ICC, 0.927), minute ventilation-carbon dioxide production relation (V˙E/V˙CO2) (r = 0.86; P < 0.001; ICC, 0.850), and peak heart rate (r = 0.95; P < 0.001; ICC, 0.944). However, high within-subject variability was observed for all CPET parameters (mean coefficient of variation, 4.7%). Compared with those for test 1, significantly higher mean values were observed for V˙O2peak (27.0 ± 5.6 vs 28.1 ± 5.3 mL·kg·min, P < 0.05), ventilatory threshold (1.91 ± 0.5 vs 1.97 ± 0.4 L·min, P < 0.05), and V˙E/V˙CO2 (31.3 ± 5.8 vs 32.8 ± 3.4, P < 0.05) in test 2.

conclusionsThese findings indicate the presence of significant, and potentially clinically important, variability in CPET procedures in men with clinically localized prostate cancer and have important implications for the application and use of CPET to evaluate the efficacy of interventions to improve aerobic capacity in the oncology setting.

Indexed as

Exercise TestAgedHeart RateHumansMaleMiddle AgedOxygen ConsumptionPhysical FitnessProstatectomyProstatic NeoplasmsPulmonary Gas ExchangePulmonary VentilationReproducibility of Results

Identifiers

PMID24781891
PMCPMC4376254
OpenAlexW2036644272

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.