Evidence map›Paper›PMID 24781689›Full record

ArticleEuropean journal of clinical nutrition2014

Infant diet and metabolic outcomes in school-age children. The Generation R Study.

O Gishti, R Gaillard, B Durmuş, A Hofman, L Duijts, O H Franco, V W V Jaddoe

Open access · bronzeAbstract read
PubMed Publisher
In one paragraph

Article in European journal of clinical nutrition, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 11 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Infant nutrition and lifelong health: current perspectives and future challenges.Journal of developmental origins of health and disease · 2015
    Review
  5. The Generation R Study: Biobank update 2015.European journal of epidemiology · 2014
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

O Gishti1] Generation R Study Group, Erasmus University Medical Center, Rotterdam, The Netherlands [2] Department of Pediatrics, Erasmus University Medical Center, Rotterdam, The Netherlands [3] Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands.
R Gaillard1] Generation R Study Group, Erasmus University Medical Center, Rotterdam, The Netherlands [2] Department of Pediatrics, Erasmus University Medical Center, Rotterdam, The Netherlands [3] Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands.
B DurmuşGeneration R Study Group, Erasmus University Medical Center, Rotterdam, The Netherlands.
A HofmanDepartment of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands.
L Duijts1] Department of Pediatrics, Erasmus University Medical Center, Rotterdam, The Netherlands [2] Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands.
O H FrancoDepartment of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands.
V W V Jaddoe1] Generation R Study Group, Erasmus University Medical Center, Rotterdam, The Netherlands [2] Department of Pediatrics, Erasmus University Medical Center, Rotterdam, The Netherlands [3] Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands.
Erasmus MC · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundBreastfeeding duration is associated with the risks of cardio-metabolic diseases in adulthood. We examined the associations of infant feeding patterns with metabolic outcomes in children and whether any association was explained by family-based socio-demographic, maternal lifestyle-related or childhood factors. SUBJECTS/

methodsWe performed a population-based prospective cohort study in 3417 children to examine the associations of breastfeeding duration and exclusivity and age at introduction of solid foods with blood levels of lipids, insulin and C-peptide and risk of clustering of cardio-metabolic risk factors at the median age of 6.0 years (90% range 5.7-6.8).

resultsWe observed that, in the models only adjusted for child's age and sex, ever breastfeeding was not associated with childhood blood levels of lipids but was associated with higher insulin and C-peptide concentrations (P-value<0.05). Breastfeeding duration and exclusivity were not consistently associated with metabolic outcomes. Early introduction of solid foods was associated with higher levels of total cholesterol (P-value<0.05) but not with high-density lipoprotein and low-density lipoprotein cholesterol, triglycerides and insulin levels. Shorter breastfeeding duration and exclusive breastfeeding were associated with increased risks of clustering of cardio-metabolic risk factors. After additional adjustment for family, maternal and childhood factors, none of these associations remained significant.

conclusionsIn conclusion, we found no consistent associations of infant feeding patterns with metabolic outcomes at school age, after taking into account family-based socio-demographic, maternal lifestyle-related or childhood factors. Whether infant diet composition influences metabolic outcomes in later life should be further studied.

Indexed as

Breast FeedingDietInfant Nutritional Physiological PhenomenaAdultCardiovascular DiseasesChildCholesterolC-Reactive ProteinFemaleHumansInfantInsulinMaleMetabolic DiseasesRisk FactorsSocioeconomic FactorsCholesterolC-Reactive ProteinInsulinTriglycerides

Identifiers

PMID24781689
OpenAlexW2018112207

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.