Trial reportAnesthesia and analgesia2014
Sedation depth during spinal anesthesia and survival in elderly patients undergoing hip fracture repair.
Trial report in Anesthesia and analgesia, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 3 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- BIS index monitoring and perioperative neurocognitive disorders in older adults: a systematic review and meta-analysis.Aging clinical and experimental research · 2020Pooled it
- Processed Electroencephalogram Monitoring and Postoperative Delirium: A Systematic Review and Meta-analysis.Anesthesiology · 2018Pooled it
- Interventions for preventing delirium in hospitalised non-ICU patients.The Cochrane database of systematic reviews · 2016Pooled it
- Effect of intraoperative remimazolam on postoperative sleep quality in elderly patients after total joint arthroplasty: a randomized control trial.Journal of anesthesia · 2023Trial
- Efficacy of the bispectral index and Observer's Assessment of Alertness/Sedation Scale in monitoring sedation during spinal anesthesia: A randomized clinical trial.The Journal of international medical research · 2020Trial
- Depth of sedation as an interventional target to reduce postoperative delirium: mortality and functional outcomes of the Strategy to Reduce the Incidence of Postoperative Delirium in Elderly Patients randomised clinical trial.British journal of anaesthesia · 2019Trial
- Effect of anesthesiaBMJ open · 2017Trial
- Adequate sedation with single-dose dexmedetomidine in patients undergoing transurethral resection of the prostate with spinal anaesthesia: a dose-response study by age group.BMC anesthesiology · 2015Trial
- The effect of bispectral index-controlled sedation on postoperative cognitive health in elderly patients with spinal anesthesia undergoing elective total knee arthroplasty: randomized, blinded study.Journal of anesthesia, analgesia and critical care · 2026Article
- The 95% effective dose of ciprofol-assisted sedation for knee arthroplasty in elderly patients: a prospective cohort study.International journal of surgery (London, England) · 2026Article
- Effects of Earmuffs and Eye Masks on Propofol Sedation during Spinal Anesthesia for Orthopedic Surgery: A Randomized Controlled Trial.Journal of clinical medicine · 2023Article
- Sedation during regional anesthesia: less is more.Canadian journal of anaesthesia = Journal canadien d'anesthesie · 2022Article
- Offline comparison of processed electroencephalogram monitors for anaesthetic-induced electroencephalogram changes in older adults.British journal of anaesthesia · 2021Article
- Application of a double reverse traction repositor in the retrograde intramedullary nailing of distal femur fractures.Journal of orthopaedic surgery and research · 2021Article
- Anesthesia and Cognitive Outcome in Elderly Patients: A Narrative Viewpoint.Journal of neurosurgical anesthesiology · 2020Review
- Results from the Adverse Event Sedation Reporting Tool: A Global Anthology of 7952 Records Derived from >160,000 Procedural Sedation Encounters.Journal of clinical medicine · 2019Article
- Article
- Hypnotic depth and postoperative death: a Bayesian perspective and an Independent Discussion of a clinical trial.British journal of anaesthesia · 2019Article
- Practical Regional Anesthesia Guide for Elderly Patients.Drugs & aging · 2019Review
- A personality trait contributes to the occurrence of postoperative delirium: a prospective study.BMC psychiatry · 2016Article
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Authors and funding
5 authors.
Funding
Abstract
Low intraoperative Bispectral Index (BIS) values may be associated with increased mortality. In a previously reported trial to prevent delirium, we randomized patients undergoing hip fracture repair under spinal anesthesia to light (BIS >80) or deep (BIS approximately 50) sedation. We analyzed survival of patients in the original trial. Among all patients, mortality was equivalent across sedation groups. However, among patients with serious comorbidities (Charlson score >4), 1-year mortality was reduced in the light (22.2%) vs deep (43.6%) sedation group (hazard ratio [HR], 0.43; 95% confidence interval, 0.19-0.97; P = 0.04) during spinal anesthesia. Similarly, among patients with Charlson score >6, 1-year mortality was reduced in the light (28.6%) vs deep (52.6%) sedation group (HR 0.33; 95% confidence interval, 0.12-0.94; P = 0.04) during spinal anesthesia. Further research on reduced mortality after light sedation during spinal anesthesia is needed.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.