ArticleJournal of the American Society for Mass Spectrometry2014
Matrix segregation as the major cause for sample inhomogeneity in MALDI dried droplet spots.
Article in Journal of the American Society for Mass Spectrometry, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 36 citations in OpenAlex.
- Quantitative Analysis of Polymers by MALDI-TOF Mass Spectrometry: Correlation Between Signal Intensity and Arm Number.Journal of mass spectrometry : JMS · 2026Article
- Advancing lignin analytics via elucidation of linkage progressions in lignin populations.Communications chemistry · 2025Article
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- Mass shift in mass spectrometry imaging: comprehensive analysis and practical corrective workflow.Analytical and bioanalytical chemistry · 2021Article
- Semiquantitative Approach for Polyester Characterization Using Matrix-Assisted Laser Desorption Ionization/Time-of-Flight Mass Spectrometry Approved byAnalytical chemistry · 2020Article
- Recommendations for quantitative analysis of small molecules by matrix-assisted laser desorption ionization mass spectrometry.Journal of chromatography. A · 2017Review
- Preparation of Homogeneous MALDI Samples for Quantitative Applications.Journal of visualized experiments : JoVE · 2016Article
- Reducing Spatial Heterogeneity of MALDI Samples with Marangoni Flows During Sample Preparation.Journal of the American Society for Mass Spectrometry · 2016Article
- Recent advances in quantitative LA-ICP-MS analysis: challenges and solutions in the life sciences and environmental chemistry.Analytical and bioanalytical chemistry · 2015Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The segregation in dried droplet MALDI sample spots was analyzed with regard to the matrix-to-sample ratio using optical microscopy, MALDI imaging mass spectrometry (MALDI MSI) and IR imaging spectroscopy. In this context, different polymer/matrix/solvent systems usually applied in the analysis of synthetic polymers were investigated. The use of typical matrix concentrations (10 mg mL⁻¹) in almost every case resulted in ring patterns, whereas higher concentrated matrix solutions always led to homogeneous sample spot layers. The data revealed that segregation is predominantly caused by matrix transport in the drying droplet, whereas polymer segregation seems to be only secondary.
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Registered trials
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