ArticleNature methods2014
Programming biological operating systems: genome design, assembly and activation.
Article in Nature methods, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
33 citing papers in PubMed.
- Synthetic Approaches as Empirical Tools for Testing Evolutionary Theory.Genome biology and evolution · 2026Review
- Engineered eMutS based magnetic separation system for high-fidelity DNA synthesis.Synthetic and systems biotechnology · 2026Article
- Discovery of functional NLRs using expression level, high-throughput transformation and large-scale phenotyping.Nature plants · 2025Article
- The design and engineering of synthetic genomes.Nature reviews. Genetics · 2025Review
- The highly rugged yet navigable regulatory landscape of the bacterial transcription factor TetR.Nature communications · 2024Article
- Leveraging Synthetic Virology for the Rapid Engineering of Vesicular Stomatitis Virus (VSV).Viruses · 2024Article
- Review
- Long oligodeoxynucleotides: chemical synthesis, isolation via catching-by-polymerization, verification via sequencing, and gene expression demonstration.Beilstein journal of organic chemistry · 2023Article
- The barley immune receptor Mla recognizes multiple pathogens and contributes to host range dynamics.Nature communications · 2021Article
- Understanding Metabolic Flux Behaviour in Whole-Cell Model Output.Frontiers in molecular biosciences · 2021Article
- Large-ScaleFrontiers in bioengineering and biotechnology · 2021Review
- Biosynthesis of adipic acid in metabolically engineered Saccharomyces cerevisiae.Journal of microbiology (Seoul, Korea) · 2020Article
- Inorganic Phosphate Solubilization by Rhizosphere BacteriumFrontiers in microbiology · 2020Article
- Redesigning the Aspergillus nidulans xylanase regulatory pathway to enhance cellulase production with xylose as the carbon and inducer source.Microbial cell factories · 2019Article
- Genome-driven cell engineering review:Essays in biochemistry · 2019Review
- Synthetic biology advances and applications in the biotechnology industry: a perspective.Journal of industrial microbiology & biotechnology · 2018Article
- UP Finder: A COBRA toolbox extension for identifying gene overexpression strategies for targeted overproduction.Metabolic engineering communications · 2017Article
- Exponential propagation of large circular DNA by reconstitution of a chromosome-replication cycle.Nucleic acids research · 2017Article
- Detailed transcriptome analysis of the plant growth promoting Paenibacillus riograndensis SBR5 by using RNA-seq technology.BMC genomics · 2017Article
- Assessing glycolytic flux alterations resulting from genetic perturbations in E. coli using a biosensor.Metabolic engineering · 2017Article
Corrections and comments
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Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The DNA technologies developed over the past 20 years for reading and writing the genetic code converged when the first synthetic cell was created 4 years ago. An outcome of this work has been an extraordinary set of tools for synthesizing, assembling, engineering and transplanting whole bacterial genomes. Technical progress, options and applications for bacterial genome design, assembly and activation are discussed.
Indexed as
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.