ArticleMammalian genome : official journal of the International Mammalian Genome Society2014
The first mouse mutants of D14Abb1e (Fam208a) show that it is critical for early development.
Article in Mammalian genome : official journal of the International Mammalian Genome Society, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 39 citations in OpenAlex.
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- TASOR expression in naive embryonic stem cells safeguards their developmental potential.Cell reports · 2024Article
- DNA methylation governs the sensitivity of repeats to restriction by the HUSH-MORC2 corepressor.Nature communications · 2024Article
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- Keep quiet: the HUSH complex in transcriptional silencing and disease.Nature structural & molecular biology · 2024Review
- The DUF3715 domain has a conserved role in RNA-directed transposon silencing.RNA (New York, N.Y.) · 2023Article
- HUSH-mediated HIV silencing is independent of TASOR phosphorylation on threonine 819.Retrovirology · 2022Article
- BAF complex-mediated chromatin relaxation is required for establishment of X chromosome inactivation.Nature communications · 2022Article
- Transposable elements shape the evolution of mammalian development.Nature reviews. Genetics · 2021Review
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- An N-ethyl-N-Nitrosourea Mutagenesis Screen in Mice Reveals a Mutation inAnimals : an open access journal from MDPI · 2021Article
- MPP8 is essential for sustaining self-renewal of ground-state pluripotent stem cells.Nature communications · 2021Article
- TASOR is a pseudo-PARP that directs HUSH complex assembly and epigenetic transposon control.Nature communications · 2020Article
- Review
- HUSH, a Link Between Intrinsic Immunity and HIV Latency.Frontiers in microbiology · 2019Review
- The HUSH complex cooperates with TRIM28 to repress young retrotransposons and new genes.Genome research · 2018Article
- Panel sequencing of 264 candidate susceptibility genes and segregation analysis in a cohort of non-BRCA1, non-BRCA2 breast cancer families.Breast cancer research and treatment · 2017Article
- The epigenetic modifier Fam208a is required to maintain epiblast cell fitness.Scientific reports · 2017Article
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
An ENU mutagenesis screen to identify novel epigenetic modifiers was established in mice carrying a multi-copy GFP transgene, which is expressed in a variegated manner in erythrocytes and is highly sensitive to epigenetic silencing. The screen has produced mouse mutants of both known modifiers of epigenetic state, such as Dnmt1 and Smarca5, and novel modifiers, such as Smchd1 and Rlf. Here we report two mouse lines generated from the screen, MommeD6 and MommeD20, with point mutations in D14Abb1e. These are the first mouse mutants of D14Abb1e (also known as Fam208a), a gene about which little is known. Heterozygous intercrosses show that homozygous mutants from both the MommeD6 and MommeD20 lines are not viable beyond gastrulation, demonstrating an important role for D14Abb1e in development. We demonstrate that haploinsufficiency for D14Abb1e effects transgene expression at the RNA level. Analysis of the predicted D14Abb1e protein sequence reveals that it contains putative nuclear localisation signals and a domain of unknown function, DUF3715. Our studies reveal that D14Abb1e is localised to the nucleus and is expressed in skin and testes.
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