ArticleForensic science, medicine, and pathology2014
The presence of enterovirus, adenovirus, and parvovirus B19 in myocardial tissue samples from autopsies: an evaluation of their frequencies in deceased individuals with myocarditis and in non-inflamed control hearts.
Article in Forensic science, medicine, and pathology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 3 of them syntheses that pooled it.
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Who cites it
17 citing papers in PubMed, 3 syntheses or guidelines pooled it, 37 citations in OpenAlex.
- Parvovirus B19-associated myocarditis in children: A systematic review of clinical features, management and outcomes.European journal of clinical investigation · 2025Pooled it
- Effect of Astragalus injection treatment for viral myocarditis: a systematic review and meta-analysis.European journal of medical research · 2025Pooled it
- Guidelines for autopsy investigation of sudden cardiac death: 2017 update from the Association for European Cardiovascular Pathology.Virchows Archiv : an international journal of pathology · 2017Guideline
- Viral cardiovascular surgical diseases: global burdens, challenges and opportunities.Future cardiology · 2024Review
- Diagnostic challenges and forensic implications in a case of infantile fatal myocarditis.Forensic science, medicine, and pathology · 2024Article
- Autopsy Histopathologic Cardiac Findings in 2 Adolescents Following the Second COVID-19 Vaccine Dose.Archives of pathology & laboratory medicine · 2022Article
- State-of-the-Art of Endomyocardial Biopsy on Acute Myocarditis and Chronic Inflammatory Cardiomyopathy.Current cardiology reports · 2022Review
- Parvovirus Infection Triggering Still's Disease.European journal of case reports in internal medicine · 2022Article
- Prevalence of cardiotropic viruses in adults with clinically suspected myocarditis in South Africa.Open heart · 2022Article
- Parvovirus B19 DNA detectable in hearts of patients with dilated cardiomyopathy, but absent or inactive in blood.ESC heart failure · 2021Article
- The spectrum of myocarditis: from pathology to the clinics.Virchows Archiv : an international journal of pathology · 2019Review
- Sudden cardiac death caused by myocarditis in persons aged 1-49 years: a nationwide study of 14 294 deaths in Denmark.Forensic sciences research · 2019Article
- Paradigm Shift in Life Sciences.Osong public health and research perspectives · 2018Article
- Roles of Host Immunity in Viral Myocarditis and Dilated Cardiomyopathy.Journal of immunology research · 2018Review
- [Lymphocytic myocarditis in a patient with metastatic clear cell renal cell carcinoma treated with Nivolumab].Der Pathologe · 2017Article
- Saffold virus infection associated with human myocarditis.Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology · 2016Article
- Acute myocarditis mimicking ST-elevation myocardial infarction: A case report and review of the literature.Experimental and therapeutic medicine · 2015Article
Corrections and comments
- Commented on byIn Reply.2022
Authors and funding
5 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeMultiple viruses have been detected in cardiac tissue, but their role in causing myocarditis remains controversial. Viral diagnostics are increasingly used in forensic medicine, but the interpretation of the results can sometimes be challenging. In this study, we examined the prevalence of adenovirus, enterovirus, and parvovirus B19 (PVB) in myocardial autopsy samples from myocarditis related deaths and in non-inflamed control hearts in an effort to clarify their significance as the causes of myocarditis in a forensic material.
methodsWe collected all autopsy cases diagnosed with myocarditis from 1992 to 2010. Eighty-four suicidal deaths with morphologically normal hearts served as controls. Polymerase chain reaction was used for the detection of the viral genomes (adenovirus, enterovirus, and PVB) in myocardial tissue specimens. The distinction between acute and persistent PVB infection was made by the serological determination of PVB-specific immunoglobulins M and G.
resultsPVB was detected in 33 of 112 (29 %) myocarditis cases and 37 of 84 (44 %) control cases. All of the samples were negative for the presence of adenovirus and enterovirus. Serological evidence of an acute PVB infection, determined by the presence of immunoglobulin M, was only present in one case. In the remaining cases, PVB was considered to be a bystander with no or limited association to myocardial inflammation.
conclusionIn this study, adenovirus, enterovirus, and PVB were found to be rare causes of myocarditis. The detection of PVB in myocardial autopsy samples most likely represents a persistent infection with no or limited association with myocardial inflammation. The forensic investigation of myocardial inflammation demands a thorough examination, including special attention to non-viral causes and requires a multidisciplinary approach.
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