Evidence map›Paper›PMID 24781083›Full record

SynthesisStroke2014

Psychological associations of poststroke fatigue: a systematic review and meta-analysis.

Simiao Wu, Amanda Barugh, Malcolm Macleod, Gillian Mead

Registry-linked trialOpen access · bronzeAbstract readMeta-AnalysisSystematic Review
In one paragraph

Synthesis in Stroke, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02131532 (A Feasibility Study of a Brief Psychological Intervention for Post-stroke Fatigue), which is not on this map. Cited by 41 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed, 5 pooled it
9.0field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02131532 phase1 / phase2completednot on this map

A Feasibility Study of a Brief Psychological Intervention for Post-stroke Fatigue

TypeinterventionalSponsorUniversity of EdinburghRan2014 to 2015Enrolled12ConditionsStrokeArmsA brief psychological intervention
3 · Its place in the literature

Who cites it

41 citing papers in PubMed, 5 syntheses or guidelines pooled it, 82 citations in OpenAlex.

  1. Pooled it
  2. Neuroimaging correlates of post-stroke fatigue: A systematic review and meta-analysis.International journal of stroke : official journal of the International Stroke Society · 2023
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  3. Related risk factors associated with post-stroke fatigue: a systematic review and meta-analysis.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2021
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  4. Interventions for post-stroke fatigue.The Cochrane database of systematic reviews · 2015
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 2 countries.

Simiao WuFrom the Centre for Clinical Brain Sciences (S.W., M.M., G.M.) and Department of Geriatric Medicine (A.B., G.M.), University of Edinburgh, Edinburgh, United Kingdom; and Department of Neurology, West China Hospital, Sichuan University, Chengdu, China (S.W.).
Amanda BarughFrom the Centre for Clinical Brain Sciences (S.W., M.M., G.M.) and Department of Geriatric Medicine (A.B., G.M.), University of Edinburgh, Edinburgh, United Kingdom; and Department of Neurology, West China Hospital, Sichuan University, Chengdu, China (S.W.).
Malcolm MacleodFrom the Centre for Clinical Brain Sciences (S.W., M.M., G.M.) and Department of Geriatric Medicine (A.B., G.M.), University of Edinburgh, Edinburgh, United Kingdom; and Department of Neurology, West China Hospital, Sichuan University, Chengdu, China (S.W.).
Gillian MeadFrom the Centre for Clinical Brain Sciences (S.W., M.M., G.M.) and Department of Geriatric Medicine (A.B., G.M.), University of Edinburgh, Edinburgh, United Kingdom; and Department of Neurology, West China Hospital, Sichuan University, Chengdu, China (S.W.). Gillian.e.mead@ed.ac.uk.
Sichuan University · CN

Funding

Medical Research Council MR/K026992/1The Dunhill Medical Trust RTF17/0111
6 · The paper itself

Abstract

background and purposeFatigue is common after stroke but has no effective treatments. Psychological interventions improve fatigue in other conditions by targeting psychological factors such as mood. If psychological factors correlate with fatigue in stroke, this would justify the development of similar interventions for poststroke fatigue (PSF). We used systematic review and meta-analysis to determine psychological associations of PSF.

methodsWe systematically searched for studies that reported psychological associations of PSF. We used odds ratios (ORs) to estimate the strength of associations and random-effects modeling to calculate summary estimates of ORs. We used stratified meta-analysis to investigate the impact of study design and conducted sensitivity analyses limited to studies that excluded patients with clinical depression and to studies that used depression scales without fatigue items.

resultsThirty-five studies (n=9268) reported the association between PSF and ≥1 psychological factor. For PSF and depressive symptoms, we identified 19 studies (n=6712; pooled OR=4.14; 95% confidence interval, 2.73-6.27); this association existed in patients without clinical depression (pooled OR=1.39; 95% confidence interval, 1.27-1.53) and in studies using depression scales without fatigue items (pooled OR=5.41; 95% confidence interval, 1.54-18.93). For PSF and anxiety, we identified 4 studies (n=3884; pooled OR=2.34; 95% confidence interval, 0.98-5.58). Two studies (n=123) found an association with poor coping styles and 1 study (n=167) with loss of control. Six studies (n=1978) reported other emotional or behavioral associations.

conclusionsPSF is associated with depressive symptoms, anxiety, poor coping, loss of control, emotional, and behavioral symptoms. These factors are potential targets for treatment of PSF.

Indexed as

Anxiety DisordersBehavioral SymptomsDepressive DisorderFatigueStress, PsychologicalStrokeAffectHumansMalebehaviorfatiguerehabilitationstroke

Identifiers

PMID24781083
PMCPMC4928705
OpenAlexW2009534082

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.