ArticleAmerican journal of epidemiology2014
Association between informal caregiving and cellular aging in the survey of the health of wisconsin: the role of caregiving characteristics, stress, and strain.
Article in American journal of epidemiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Mortality, Morbidity and Health-Related Outcomes in Informal Caregivers Compared to Non-Caregivers: A Systematic Review.International journal of environmental research and public health · 2022Pooled it
- Objective Physical Activity and Sedentary Behaviour Patterns Among Informal Carers in the BCS70 Cohort.International journal of environmental research and public health · 2026Article
- Relationship between cellular aging, perceived stress, and cardiometabolic disease risk in Black family caregivers of persons with dementia.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Place-based, intersectional variation in caregiving patterns and health outcomes among informal caregivers in the United States.Frontiers in public health · 2024Article
- Examining the Rationale for Studying Psychedelic-Assisted Psychotherapy for the Treatment of Caregiver Distress.Psychedelic medicine (New Rochelle, N.Y.) · 2023Review
- Gender Differences in Perceived Stress and Its Relationship to Telomere Length in Costa Rican Adults.Frontiers in psychology · 2022Article
- Article
- The Survey of the Health of Wisconsin (SHOW) Program: An Infrastructure for Advancing Population Health.Frontiers in public health · 2022Article
- The Survey of the Health of Wisconsin (SHOW) Program: An infrastructure for Advancing Population Health Sciences.medRxiv : the preprint server for health sciences · 2021Article
- Quality of life, tuberculosis and treatment outcome; a case-control and nested cohort study.The European respiratory journal · 2020Article
- Family caregiving in the community up to 8-years after onset of dementia.BMC geriatrics · 2020Article
- Chronic psychosocial and financial burden accelerates 5-year telomere shortening: findings from the Coronary Artery Risk Development in Young Adults Study.Molecular psychiatry · 2020Article
- Controlling for baseline telomere length biases estimates of the rate of telomere attrition.Royal Society open science · 2019Article
- Cumulative lifetime stress exposure and leukocyte telomere length attrition: The unique role of stressor duration and exposure timing.Psychoneuroendocrinology · 2019Article
- Years of caregiving for chronically ill and disabled family members is not associated with telomere length in the Philippines.Psychoneuroendocrinology · 2019Article
- A scoping systematic review of social stressors and various measures of telomere length across the life course.Ageing research reviews · 2018Article
- The Role of Biomarkers in Research on Caregivers for Cancer Patients: A Scoping Review.Biological research for nursing · 2018Article
- Relation of long-term patterns in caregiving activity and depressive symptoms to telomere length in older women.Psychoneuroendocrinology · 2018Article
- Test anxiety and telomere length: Academic stress in adolescents may not cause rapid telomere erosion.Oncotarget · 2017Article
- Lifespan adversity and later adulthood telomere length in the nationally representative US Health and Retirement Study.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
The pathophysiological consequences of caregiving have not been fully elucidated. We evaluated how caregiving, stress, and caregiver strain were associated with shorter relative telomere length (RTL), a marker of cellular aging. Caregivers (n = 240) and some noncaregivers (n = 98) in the 2008-2010 Survey of the Health of Wisconsin, comprising a representative sample of Wisconsin adults aged 21-74 years, reported their sociodemographic, health, and psychological characteristics. RTL was assayed from blood or saliva samples. Median T and S values were used to determine the telomere-to-single copy gene ratio (T/S) for each sample, and log(T/S) was used as the dependent variable in analyses. Multivariable generalized additive models showed that RTL did not differ between caregivers and noncaregivers (difference in log(T/S) = -0.03; P > 0.05), but moderate-to-high levels of stress versus low stress were associated with longer RTL (difference = 0.15; P = 0.04). Among caregivers, more hours per week of care, caring for a young person, and greater strain were associated with shorter RTL (P < 0.05). Caregivers with discordant levels of stress and strain (i.e., low perceived stress/high strain) compared with low stress/low strain had the shortest RTL (difference = -0.24; P = 0.02, Pinteraction = 0.13), corresponding to approximately 10-15 additional years of aging. Caregivers with these characteristics may be at increased risk for accelerated aging. Future work is necessary to better elucidate these relationships and develop interventions to improve the long-term health and well-being of caregivers.
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