ArticleNeuroscience2014
Serotonin modulates electrosensory processing and behavior via 5-HT2-like receptors.
Article in Neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
13 citing papers in PubMed, 29 citations in OpenAlex.
- In vivo neural activity of electrosensory pyramidal cells: Biophysical characterization and phenomenological modeling.PLoS computational biology · 2025Article
- Article
- Neuroendocrine mechanisms contributing to the coevolution of sociality and communication.Frontiers in neuroendocrinology · 2023Review
- Vocal and Electric Fish: Revisiting a Comparison of Two Teleost Models in the Neuroethology of Social Behavior.Frontiers in neural circuits · 2021Review
- Serotonergic Modulation of Sensory Neuron Activity and Behavior inFrontiers in integrative neuroscience · 2020Article
- Descending pathways mediate adaptive optimized coding of natural stimuli in weakly electric fish.Science advances · 2019Article
- Encoding and Perception of Electro-communication Signals inFrontiers in integrative neuroscience · 2019Review
- Differences in Sodium Channel Densities in the Apical Dendrites of Pyramidal Cells of the Electrosensory Lateral Line Lobe.Frontiers in neural circuits · 2019Article
- Descending pathways generate perception of and neural responses to weak sensory input.PLoS biology · 2018Article
- Temporal decorrelation by SK channels enables efficient neural coding and perception of natural stimuli.Nature communications · 2016Article
- Electrosensory Midbrain Neurons Display Feature Invariant Responses to Natural Communication Stimuli.PLoS computational biology · 2015Article
- Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Efficient sensory processing of the environment is a critical function for any organism to survive and is accomplished by having neurons adapt their responses to stimuli based on behavioral context in part through neuromodulators such as serotonin (5-HT). We have recently shown that one critical function of the serotonergic system in weakly electric fish is to enhance sensory pyramidal neuron responses within the electrosensory lateral line lobe (ELL) to stimuli caused by same sex conspecifics, thereby enhancing their perception. This enhancement is accomplished by making pyramidal neurons more excitable through downregulation of potassium channels. However, the nature of the 5-HT receptors that mediate this effect is not known. Here we show that the 5-HT2 receptor antagonist ketanserin (ket) can effectively block the effects of 5-HT on pyramidal neuron excitability in vitro. Indeed, 5-HT application subsequent to ket application did not cause any significant changes in neuron excitability and responses to current injection. We further show that ket applied in vivo can block the effects of 5-HT on behavioral responses. Thus, our results strongly suggest that the previously observed effects of 5-HT on sensory processing within ELL and their consequences for behavior are mediated by 5-HT2 receptors.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.