ArticleClinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association2014
Sleep duration affects risk for ulcerative colitis: a prospective cohort study.
Article in Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers, 2 of them syntheses that pooled it.
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Who cites it
59 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Impact of nursing shift patterns on work-related gastrointestinal disorders: a systematic review and meta-analysis.Frontiers in public health · 2026Pooled it
- Sleep Disturbances, Fatigue and Immune Markers in the Irritable Bowel Syndrome and Inflammatory Bowel Disease, a Systematic Review.Neurogastroenterology and motility · 2025Pooled it
- The exposome and inflammatory bowel disease: a framework for primary and primordial prevention.Nature reviews. Gastroenterology & hepatology · 2026Review
- Associations of Circadian Clock Gene Variants with Clinical Features and Treatment Characteristics in Ulcerative Colitis.Journal of clinical medicine · 2026Article
- The association between nighttime sleep duration and digestive diseases in middle-aged and older population in China: mediating role of depression.BMC public health · 2026Article
- Postbiotic Metabolites from a 31-StrainBiology · 2026Article
- Long-term risk of bowel resection and mortality associated with sleep behaviours and sleep pattern in patients with inflammatory bowel disease: a large-scale prospective cohort study.Family medicine and community health · 2026Article
- Exposure to outdoor artificial light at night is associated with a higher risk of ulcerative colitis: a prospective cohort study from the UK Biobank.Frontiers in public health · 2026Article
- Sleep fragmentation frequency is associated with distinct immune, microbial, and barrier-related profiles in DSS-induced colitis in mice.Frontiers in immunology · 2026Article
- Large-scale plasma proteomics reveals bidirectional associations between sleep patterns and inflammatory bowel disease: a prospective cohort study.BMC medicine · 2025Article
- Association of healthy lifestyle, metabolic alterations and lower mortality risk of IBD patients: a prospective cohort and mediation analysis.Family medicine and community health · 2025Article
- Associations between nighttime sleep duration trajectories and risk of digestive diseases among middle-aged and older Chinese adults.Sleep & breathing = Schlaf & Atmung · 2025Article
- Autoantibodies against endothelial protein C receptor and integrin αvβ6 predict the development of ulcerative colitis.Journal of gastroenterology · 2025Article
- Environmental risk factors of inflammatory bowel disease: toward a strategy of preventative health.Journal of Crohn's & colitis · 2025Review
- Microbial melatonin metabolism in the human intestine as a therapeutic target for dysbiosis and rhythm disorders.NPJ biofilms and microbiomes · 2024Review
- The Potential Role of Plant Polysaccharides in Treatment of Ulcerative Colitis.Pharmaceutics · 2024Review
- Risk of heart failure in inflammatory bowel disease: a Swedish population-based study.European heart journal · 2024Article
- Effect of Urolithin A on the Improvement of Circadian Rhythm Dysregulation in Intestinal Barrier Induced by Inflammation.Nutrients · 2024Article
- Insomnia is common in inflammatory bowel disease (IBD) and is associated with mental health conditions as well as IBD activity.Intestinal research · 2024Article
- Depression influences fatigue in inflammatory bowel disease amongst other factors: a structural modelling approach.Therapeutic advances in gastroenterology · 2024Article
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Abstract
BACKGROUND &
aimsSleep deprivation is associated with production of inflammatory cytokines. Disturbed sleep quality has been associated with increased risk of disease flare in patients with Crohn's disease (CD) or ulcerative colitis (UC). However, the association between sleep and risk of incident CD and UC has not been previously examined.
methodsWe conducted a prospective study of women who were enrolled in the Nurses' Health Study (NHS) I since 1976 and NHS II since 1989 and followed through detailed biennial questionnaires with >90% follow-up. We examined the association of sleep duration reported in 1986 in NHS I and 2001 in NHS II with incident CD and UC, diagnosed through 2010, in NHS I and 2009 in NHS II. Cox proportional hazards models adjusting for potential confounders were used to calculate hazard ratios and 95% confidence intervals (CIs).
resultsAmong 151,871 women, we confirmed 191 cases of CD (incidence, 8/100,000 person-years) and 230 cases of UC (incidence, 10/100,000 person-years) over 2,292,849 person-years. Compared with women with reported usual sleep durations of 7-8 h/day (incidence, 8/100,000 person-years), women with reported sleep duration <6 h/day (11/100,000 person-years) or >9 h/day (20/100,000 person-years) had a higher incidence of UC (P < .05). The multivariate hazard ratios for UC were 1.51 (95% CI, 1.10-2.09) for sleep durations <6 h/day and 2.05 (95% CI, 1.44-2.92) for sleep durations >9 h/day, compared with sleep durations of 7-8 h/day. In contrast, sleep duration did not modify risk of CD. Duration of rotating night shift work was not associated with CD or UC.
conclusionsOn the basis of data from the NHS I and II, less than 6 hours sleep/day and more than 9 hours sleep/day are each associated with an increased risk of UC. Further studies are needed to evaluate sleep as a modifiable risk factor in the pathogenesis and progression of IBD.
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