ArticleMedical hypotheses2014
Autism as a sequence: from heterochronic germinal cell divisions to abnormalities of cell migration and cortical dysplasias.
Article in Medical hypotheses, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
23 citing papers in PubMed.
- Auts2 enhances neurogenesis and promotes expansion of the cerebral cortex.Journal of advanced research · 2025Article
- Loss of protein tyrosine phosphatase receptor delta PTPRD increases the number of cortical neurons, impairs synaptic function and induces autistic-like behaviors in adult mice.Biological research · 2024Article
- Viruses and autism: A Bi-mutual cause and effect.World journal of virology · 2023Review
- 16p11.2 deletion accelerates subpallial maturation and increases variability in human iPSC-derived ventral telencephalic organoids.Development (Cambridge, England) · 2023Article
- Pathology and Astrocytes in Autism.Neuropsychiatric disease and treatment · 2023Review
- White matter microstructural and morphometric alterations in autism: implications for intellectual capabilities.Molecular autism · 2022Article
- Ringing Decay of Gamma Oscillations and Transcranial Magnetic Stimulation Therapy in Autism Spectrum Disorder.Applied psychophysiology and biofeedback · 2021Article
- ATF5 deficiency causes abnormal cortical development.Scientific reports · 2021Article
- Hyperactive Behavior and Altered Brain Morphology in Adult Complement C3a Receptor Deficient Mice.Frontiers in immunology · 2021Article
- Understanding the clinical manifestations of 16p11.2 deletion syndrome: a series of developmental case reports in children.Psychiatric genetics · 2020Article
- Transcranial Magnetic Stimulation in Autism Spectrum Disorders: Neuropathological Underpinnings and Clinical Correlations.Seminars in pediatric neurology · 2020Review
- Transdisciplinary Approach Practicum for Speech-Language Pathology and Special Education Graduate Students.Journal of autism and developmental disorders · 2020Article
- Cerebral organoids as tools to identify the developmental roots of autism.Molecular autism · 2020Review
- The modular organization of the cerebral cortex: Evolutionary significance and possible links to neurodevelopmental conditions.The Journal of comparative neurology · 2019Review
- Role ofMolecular autism · 2018Article
- Epigenetic regulation of RELN and GAD1 in the frontal cortex (FC) of autism spectrum disorder (ASD) subjects.International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience · 2017Article
- Perturbed Wnt signaling leads to neuronal migration delay, altered interhemispheric connections and impaired social behavior.Nature communications · 2017Article
- Psychiatric behaviors associated with cytoskeletal defects in radial neuronal migration.Cellular and molecular life sciences : CMLS · 2017Review
- In Vivo Evidence of Reduced Integrity of the Gray-White Matter Boundary in Autism Spectrum Disorder.Cerebral cortex (New York, N.Y. : 1991) · 2017Article
- Prenatal Exposure to Autism-Specific Maternal Autoantibodies Alters Proliferation of Cortical Neural Precursor Cells, Enlarges Brain, and Increases Neuronal Size in Adult Animals.Cerebral cortex (New York, N.Y. : 1991) · 2016Article
Corrections and comments
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Authors and funding
1 author.
Funding
Abstract
The considerable heterogeneity in the number and severity of symptoms observed in autism spectrum disorders (ASD) has been regarded as an obstacle to any future research. Some authors believe that clinical heterogeneity results from the complex interplay of the many genetic and environmental factors that themselves define a condition as multifactorial. However, it is important to note that neuropathological findings in both idiopathic and syndromic autism suggests a single pathophysiological mechanism acting during brain development: the heterochronic division of germinal cells and subsequent migrational abnormalities of daughter cells to their target fields. Multiple exogenous (e.g., viruses, drugs) and endogenous (e.g., genetic mutations) factors are known to disrupt the division of germinal cells and provide for an autism phenotype. The variety of endogenous and exogenous factors, their timing of action during brain development, and the genetic susceptibility of affected individuals (a Triple Hit hypothesis) may all account for the clinical heterogeneity of ASD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.