ArticleBiomaterials2014
Effect of the interplay between protein and surface on the properties of adsorbed protein layers.
Article in Biomaterials, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed.
- Advances in Biomaterials for Tissue Regeneration: From Scaffold Design to CAP-Enabled Interfaces and AI-Driven Optimization.Biomimetics (Basel, Switzerland) · 2026Review
- Tailored Xenogeneic-Free Polymer Surface Promotes Dynamic Migration of Intestinal Stem Cells.Advanced materials (Deerfield Beach, Fla.) · 2026Article
- Role of the Surface in Conformational Changes in Lysozymes: Effect of a Gold Surface and a Lipid Membrane.International journal of molecular sciences · 2025Article
- Prospects and challenges of recombinant spider venom enzymes: insights fromFrontiers in bioengineering and biotechnology · 2025Article
- Sensing the Future-Frontiers in Biosensors: Exploring Classifications, Principles, and Recent Advances.ACS omega · 2024Review
- Histidine-rich glycoprotein attenuates catheter thrombosis.Blood advances · 2023Article
- Quartz Crystal Microbalance Application andLangmuir : the ACS journal of surfaces and colloids · 2023Article
- Electrode Potential-Dependent Studies of Protein Adsorption on TiMolecules (Basel, Switzerland) · 2023Article
- Next-generation biomaterials for dental pulp tissue immunomodulation.Dental materials : official publication of the Academy of Dental Materials · 2023Review
- Characterization of the Protein Corona of Three Chairside Hemoderivatives on Melt Electrowritten Polycaprolactone Scaffolds.International journal of molecular sciences · 2023Article
- Bio-inspired hemocompatible surface modifications for biomedical applications.Progress in materials science · 2022Article
- Fabrication of Gold Nanostructures on Quartz Crystal Microbalance Surface Using Nanoimprint Lithography for Sensing Applications.Micromachines · 2022Article
- Advanced Drug Delivery Modulation via Hybrid Nanofibers Enhances Stem Cell Differentiation.ACS applied materials & interfaces · 2022Article
- Dielectric Spectroscopy Can Predict the Effect of External AC Fields on the Dynamic Adsorption of Lysozyme.Chemphyschem : a European journal of chemical physics and physical chemistry · 2022Article
- Selective Separation of Highly Similar Proteins on Ionic Liquid-Loaded Mesoporous TiOLangmuir : the ACS journal of surfaces and colloids · 2022Article
- Effect of acid-alkali treatment on serum protein adsorption and bacterial adhesion to porous titanium.Journal of materials science. Materials in medicine · 2022Article
- Progress in Vocal Fold Regenerative Biomaterials: An Immunological Perspective.Advanced nanobiomed research · 2022Article
- Tissue Engineering Meets Nanotechnology: Molecular Mechanism Modulations in Cornea Regeneration.Micromachines · 2021Review
- Predicting the In Vivo Performance of Cardiovascular Biomaterials: Current Approaches In Vitro Evaluation of Blood-Biomaterial Interactions.International journal of molecular sciences · 2021Review
- Biomaterial-directed cell behavior for tissue engineering.Current opinion in biomedical engineering · 2021Article
Corrections and comments
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Authors and funding
3 authors.
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Abstract
Although protein adsorption to surface is a common phenomenon, investigation of the process is challenging due to the complexity of the interplay between external factors, protein and surface properties. Therefore experimental approaches have to measure the properties of adsorbed protein layers with high accuracy in order to achieve a comprehensive description of the process. To this end, we used a combination of two biosensing techniques, dual polarization interferometry and quartz crystal microbalance with dissipation. From this, we are able to extract surface coverage values, layer structural parameters, water content and viscoelastic properties to examine the properties of protein layers formed at the liquid/solid interface. Layer parameters were examined upon adsorption of proteins of varying size and structural properties, on surfaces with opposite polarity. We show that "soft" proteins such as unfolded α-synuclein and high molecular weight albumin are highly influenced by the surface polarity, as they form a highly diffuse and hydrated layer on the hydrophilic silica surface as opposed to the denser, less hydrated layer formed on a hydrophobic methylated surface. These layer properties are a result of different orientations and packing of the proteins. By contrast, lysozyme is barely influenced by the surface polarity due to its intrinsic structural stability. Interestingly, we show that for a similar molecular weight, the unfolded α-synuclein forms a layer with the highest percentage of solvation not related to surface coverage but resulting from the highest water content trapped within the protein. Together, these data reveal a trend in layer properties highlighting the importance of the interplay between protein and surface for the design of biomaterials.
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Registered trials
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