Evidence map›Paper›PMID 24779022›Full record

ReviewBioMed research international2014

Cellular players in skeletal muscle regeneration.

Laura Cristina Ceafalan, Bogdan Ovidiu Popescu, Mihail Eugen Hinescu

Abstract readReview
In one paragraph

Review in BioMed research international, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers.

0numbers the graph read from it
0cells of the map it votes in
60citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

60 citing papers in PubMed.

  1. Review
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  6. Review
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  10. Review
  11. Article
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  13. Identification and protective role of CD34Histochemistry and cell biology · 2023
    Article
  14. Review
  15. Article
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  19. Telocytes: An Emerging Component of Stem Cell Niche Microenvironment.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2021
    Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Laura Cristina CeafalanDepartment of Cell Biology and Histology, School of Medicine, "Carol Davila" University of Medicine and Pharmacy, 8 Eroii Sanitari, 050474 Bucharest, Romania ; Department of Molecular Medicine and Neuroscience, "Victor Babes," Institute of Pathology, 99-101 Splaiul Independentei, 050096 Bucharest, Romania.
Bogdan Ovidiu PopescuDepartment of Molecular Medicine and Neuroscience, "Victor Babes," Institute of Pathology, 99-101 Splaiul Independentei, 050096 Bucharest, Romania ; Department of Neurology, Colentina Clinical Hospital (CDPC), School of Medicine, "Carol Davila" University of Medicine and Pharmacy, 19-21 Sos. Stefan cel Mare, 020125 Bucharest, Romania.
Mihail Eugen HinescuDepartment of Cell Biology and Histology, School of Medicine, "Carol Davila" University of Medicine and Pharmacy, 8 Eroii Sanitari, 050474 Bucharest, Romania ; Department of Molecular Medicine and Neuroscience, "Victor Babes," Institute of Pathology, 99-101 Splaiul Independentei, 050096 Bucharest, Romania.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Skeletal muscle, a tissue endowed with remarkable endogenous regeneration potential, is still under focused experimental investigation mainly due to treatment potential for muscle trauma and muscular dystrophies. Resident satellite cells with stem cell features were enthusiastically described quite a long time ago, but activation of these cells is not yet controlled by any medical interventions. However, after thorough reports of their existence, survival, activation, and differentiation there are still many questions to be answered regarding the intimate mechanism of tissue regeneration. This review delivers an up-to-date inventory of the main known key players in skeletal muscle repair, revealed by various models of tissue injuries in mechanical trauma, toxic lesions, and muscular dystrophy. A better understanding of the spatial and temporal relationships between various cell populations, with different physical or paracrine interactions and phenotype changes induced by local or systemic signalling, might lead to a more efficient approach for future therapies.

Indexed as

RegenerationCell DifferentiationCell LineageHumansMuscle, SkeletalMuscular DystrophiesSignal TransductionStem CellsStem Cell Transplantation

Identifiers

PMID24779022
PMCPMC3980925

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.