ReviewAutoimmune diseases2014
Aspirin for prevention of preeclampsia in lupus pregnancy.
Review in Autoimmune diseases, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 49 citations in OpenAlex.
- [Impact of aspirin use on pregnancy outcomes in patients with systemic lupus erythematosus].Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences · 2025Article
- Association of preterm outcome with maternal systemic lupus erythematosus: a retrospective cohort study.Italian journal of pediatrics · 2023Article
- Development of a Set of Lupus-Specific, Ambulatory Care-Sensitive, Potentially Preventable Adverse Conditions: A Delphi Consensus Study.Arthritis care & research · 2021Review
- Pharmacological Approach to Managing Childhood-Onset Systemic Lupus Erythematosus During Conception, Pregnancy and Breastfeeding.Paediatric drugs · 2018Review
- Postpartum nephrotic syndrome related to new onset of systemic lupus erythematosus: A case report.Case reports in women's health · 2018Article
- Pregnancy outcomes among Chinese women with and without systemic lupus erythematosus: a retrospective cohort study.BMJ open · 2018Article
- Management and outcomes of pregnancy with or without lupus nephritis: a systematic review and meta-analysis.Therapeutics and clinical risk management · 2018Review
- Pregnancy: An Underutilized Window of Opportunity to Improve Long-term Maternal and Infant Health-An Appeal for Continuous Family Care and Interdisciplinary Communication.Frontiers in pediatrics · 2017Review
- The impact of unrecognized autoimmune rheumatic diseases on the incidence of preeclampsia and fetal growth restriction: a longitudinal cohort study.BMC pregnancy and childbirth · 2016Article
- Immunohistochemical Expression of Myeloperoxidase in Placental Samples of Systematic Lupus Erythematosus Pregnancies.Journal of family & reproductive health · 2016Article
- The clinical significance of antiphospholipid antibodies in systemic lupus erythematosus.European journal of rheumatology · 2016Review
- Evaluation the effect of low-dose aspirin on endothelial dysfunction in preeclamptic patients.Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2016Article
- Angiogenic factor imbalance early in pregnancy predicts adverse outcomes in patients with lupus and antiphospholipid antibodies: results of the PROMISSE study.American journal of obstetrics and gynecology · 2016Article
- Lack of Thromboxane Synthase Prevents Hypertension and Fetal Growth Restriction after High Salt Treatment during Pregnancy.PloS one · 2016Article
- Mechanisms of Endothelial Dysfunction in Hypertensive Pregnancy and Preeclampsia.Advances in pharmacology (San Diego, Calif.) · 2016Article
- Systemic lupus erythematosus: strategies to improve pregnancy outcomes.International journal of women's health · 2016Review
- Differences in Liver Injury and Trophoblastic Mitochondrial Damage in Different Preeclampsia-like Mouse Models.Chinese medical journal · 2015Article
- Adjudin--A Male Contraceptive with Other Biological Activities.Recent patents on endocrine, metabolic & immune drug discovery · 2015Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Preeclampsia, the onset of hypertension and proteinuria during pregnancy, is a common medical disorder with high maternal and fetal mortality and morbidity. The underlying pathology remains poorly understood and includes inflammation, endothelial dysfunction, and an unbalanced thromboxane A2/prostacyclin ratio. For women with systemic lupus erythematosus (SLE), particularly those with preexisting renal disease or with active lupus, the risk of developing preeclampsia is up to 14% higher than it is among healthy individuals. The mechanism is still unknown and the data for preventing preeclampsia in lupus pregnancies are rare. Modulating the impaired thromboxane A2/prostacyclin ratio by administration of low-dose aspirin appears to be the current best option for the prevention of preeclampsia. After providing an overview of the pathogenesis of preeclampsia, preeclampsia in lupus pregnancies, and previous trials for prevention of preeclampsia with aspirin treatment, we recommend low-dose aspirin administration for all lupus patients starting prior to 16 weeks of gestation. Patients with SLE and antiphospholipid syndrome should receive treatment with heparin and low-dose aspirin during pregnancy.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.