Evidence map›Paper›PMID 24778716›Full record

ArticleBeilstein journal of organic chemistry2014

Synthesis of chiral N-phosphinyl α-imino esters and their application in asymmetric synthesis of α-amino esters by reduction.

Yiwen Xiong, Haibo Mei, Lingmin Wu, Jianlin Han, Yi Pan, Guigen Li

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Beilstein journal of organic chemistry, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Yiwen XiongSchool of Chemistry and Chemical Engineering, State of Key Laboratory of Coordination, Nanjing University, Nanjing, 210093, China.
Haibo MeiSchool of Chemistry and Chemical Engineering, State of Key Laboratory of Coordination, Nanjing University, Nanjing, 210093, China ; Institute for Chemistry & BioMedical Sciences, Nanjing University, Nanjing, 210093, China.
Lingmin WuSchool of Chemistry and Chemical Engineering, State of Key Laboratory of Coordination, Nanjing University, Nanjing, 210093, China.
Jianlin HanSchool of Chemistry and Chemical Engineering, State of Key Laboratory of Coordination, Nanjing University, Nanjing, 210093, China ; Institute for Chemistry & BioMedical Sciences, Nanjing University, Nanjing, 210093, China ; High-Tech Research Institute of Nanjing University, Changzhou, 213164, China.
Yi PanSchool of Chemistry and Chemical Engineering, State of Key Laboratory of Coordination, Nanjing University, Nanjing, 210093, China.
Guigen LiInstitute for Chemistry & BioMedical Sciences, Nanjing University, Nanjing, 210093, China ; Department of Chemistry and Biochemistry, Texas Tech University, Lubbock, Texas, 79409-1061, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A variety of chiral N-phosphinyl α-imino esters have been synthesized for the first time from ketoesters and phosphinylamide, which were then reduced by L-selectride to give the corresponding N-phosphinyl-protected α-amino esters. The reduction proceeded very well with excellent chemical yields (88-98%) as well as high diastereoselectivities (96:4 to 99:1). Some of these products could be obtained without column chromatography and recrystallization. The chiral phosphinyl auxiliary could be easily cleaved under acidic conditions.

Indexed as

group-assisted purificationphosphinyl auxiliaryreductionα-amino esterα-imino ester

Identifiers

PMID24778716
PMCPMC3999852

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.