ReviewFrontiers in physiology2014
Arterial pressure and cerebral blood flow variability: friend or foe? A review.
Review in Frontiers in physiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
37 citing papers in PubMed, 1 synthesis or guideline pooled it, 77 citations in OpenAlex.
- Association Between Blood Pressure Variability With Dementia and Cognitive Impairment: A Systematic Review and Meta-Analysis.Hypertension (Dallas, Tex. : 1979) · 2021Pooled it
- Enhancement of Cerebral Oxygenation by Lower-Limb Neuromuscular Electrical Stimulation in Stroke Survivors.Annals of biomedical engineering · 2026Observational
- Reproducibility of a time-resolved NIRS, multidistance diffuse correlation spectroscopy system: towards noninvasive longitudinal neuromonitoring.Neurophotonics · 2026Article
- Acute cardiovascular and cerebral blood flow responses to high frequency, low amplitude vibration on the neck.Journal of applied physiology (Bethesda, Md. : 1985) · 2025Article
- Association between low-frequency oscillations in blood pressure variability and brain age derived from neuroimaging.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- A KNN-based model for non-invasive prediction of hemorrhagic shock severity in prehospital settings: integrating MAP, PBiomedical engineering online · 2025Article
- Association of systolic blood pressure variability with remote ischemic conditioning in acute ischemic stroke.Scientific reports · 2024Article
- Association of Blood Pressure Variability with Delirium in Patients with Critical Illness.Neurocritical care · 2023Observational
- Using ex vivo arterial injection and dissection to assess white matter vascularization.Scientific reports · 2023Article
- Cerebral hemodynamics comparison using transcranial doppler ultrasound and 4D flow MRI.Frontiers in physiology · 2023Article
- The potential therapeutic benefits of low frequency haemodynamic oscillations.The Journal of physiology · 2022Article
- Integrative physiological assessment of cerebral hemodynamics and metabolism in acute ischemic stroke.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2022Review
- The effect of blood pressure variability on the prognosis of patients with acute cerebral hemorrhage: Possible mechanism.Frontiers in neuroscience · 2022Article
- Low frequency cerebral arterial and venous flow oscillations in healthy neonates measured by NeoDoppler.Frontiers in pediatrics · 2022Article
- Cerebroarterial pulsatility and resistivity indices are associated with cognitive impairment and white matter hyperintensity in elderly subjects: A phase-contrast MRI study.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2021Article
- Impact of oralAmerican journal of cardiovascular disease · 2021Article
- Reliability of quantitative transverse relaxation time mapping with [Formula: see text]-prepared whole brain pCASL.Scientific reports · 2020Article
- The short-term effects of sedentary behaviour on cerebral hemodynamics and cognitive performance in older adults: a cross-over design on the potential impact of mental and/or physical activity.Alzheimer's research & therapy · 2020Article
- Day-to-day blood pressure variability is associated with lower cognitive performance among the Japanese community-dwelling oldest-old population: the SONIC study.Hypertension research : official journal of the Japanese Society of Hypertension · 2020Article
- NeoDoppler: New ultrasound technology for continous cerebral circulation monitoring in neonates.Pediatric research · 2020Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Variability in arterial pressure and cerebral blood flow has traditionally been interpreted as a marker of cardiovascular decompensation, and has been associated with negative clinical outcomes across varying time scales, from impending orthostatic syncope to an increased risk of stroke. Emerging evidence, however, suggests that increased hemodynamic variability may, in fact, be protective in the face of acute challenges to perfusion, including significant central hypovolemia and hypotension (including hemorrhage), and during cardiac bypass surgery. This review presents the dichotomous views on the role of hemodynamic variability on clinical outcome, including the physiological mechanisms underlying these patterns, and the potential impact of increased and decreased variability on cerebral perfusion and oxygenation. We suggest that reconciliation of these two apparently discrepant views may lie in the time scale of hemodynamic variability; short time scale variability appears to be cerebroprotective, while mid to longer term fluctuations are associated with primary and secondary end-organ dysfunction.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.