ReviewFrontiers in behavioral neuroscience2014
Learning to smell danger: acquired associative representation of threat in the olfactory cortex.
Review in Frontiers in behavioral neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
26 citing papers in PubMed, 51 citations in OpenAlex.
- Task-dependent functional connectivity of pain is associated with the magnitude of placebo analgesia in pain-free individuals.European journal of pain (London, England) · 2023Trial
- Threat Memory in the Sensory Cortex: Insights from Olfaction.The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry · 2024Review
- Olfactory threat extinction in the piriform cortex: An age-dependent employment of NMDA receptor-dependent long-term depression.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- The Basolateral Amygdala: The Core of a Network for Threat Conditioning, Extinction, and Second-Order Threat Conditioning.Biology · 2023Review
- Sensing fear: fast and precise threat evaluation in human sensory cortex.Trends in cognitive sciences · 2023Review
- A comparative neuroimaging perspective of olfaction and higher-order olfactory processing: on health and disease.Seminars in cell & developmental biology · 2022Review
- Pattern differentiation and tuning shift in human sensory cortex underlie long-term threat memory.Current biology : CB · 2022Article
- Human Sensory Cortex Contributes to the Long-Term Storage of Aversive Conditioning.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Impaired early visual categorization of fear in social anxiety.Psychophysiology · 2020Article
- A network model of affective odor perception.PloS one · 2020Article
- An Evolutionarily Threat-Relevant Odor Strengthens Human Fear Memory.Frontiers in neuroscience · 2020Article
- Article
- Human chemosignals of disgust facilitate food judgment.Scientific reports · 2018Article
- Brain structural correlates of irritability: Findings in a large healthy cohort.Human brain mapping · 2017Article
- Behavioral and neural correlates to multisensory detection of sick humans.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Poor human olfaction is a 19th-century myth.Science (New York, N.Y.) · 2017Review
- Amygdalar Gating of Early Sensory Processing through Interactions with Locus Coeruleus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- Ecologically relevant neurobehavioral assessment of the development of threat learning.Learning & memory (Cold Spring Harbor, N.Y.) · 2016Review
- Decomposing fear perception: A combination of psychophysics and neurometric modeling of fear perception.Neuropsychologia · 2016Article
- Development of Odor Hedonics: Experience-Dependent Ontogeny of Circuits Supporting Maternal and Predator Odor Responses in Rats.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
Neuroscience research over the past few decades has reached a strong consensus that the amygdala plays a key role in emotion processing. However, many questions remain unanswered, especially concerning emotion perception. Based on mnemonic theories of olfactory perception and in light of the highly associative nature of olfactory cortical processing, here I propose a sensory cortical model of olfactory threat perception (i.e., sensory-cortex-based threat perception): the olfactory cortex stores threat codes as acquired associative representations (AARs) formed via aversive life experiences, thereby enabling encoding of threat cues during sensory processing. Rodent and human research in olfactory aversive conditioning was reviewed, indicating learning-induced plasticity in the amygdala and the olfactory piriform cortex. In addition, as aversive learning becomes consolidated in the amygdala, the associative olfactory (piriform) cortex may undergo (long-term) plastic changes, resulting in modified neural response patterns that underpin threat AARs. This proposal thus brings forward a sensory cortical pathway to threat processing (in addition to amygdala-based processes), potentially accounting for an alternative mechanism underlying the pathophysiology of anxiety and depression.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.