ArticleProceedings of the National Academy of Sciences of the United States of America1989
Expression of Drosophila Shaker potassium channels in mammalian cells infected with recombinant vaccinia virus.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1989. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
8 citing papers in PubMed, 26 citations in OpenAlex.
- Roles for Countercharge in the Voltage Sensor Domain of Ion Channels.Frontiers in pharmacology · 2020Review
- Gating of the shaker potassium channel is modulated differentially by N-glycosylation and sialic acids.Pflugers Archiv : European journal of physiology · 2008Article
- Genetically engineered poxviruses for recombinant gene expression, vaccination, and safety.Proceedings of the National Academy of Sciences of the United States of America · 1996Review
- Slow and incomplete inactivations of voltage-gated channels dominate encoding in synthetic neurons.Biophysical journal · 1993Article
- Structure and regulation of the MinK potassium channel.Neurochemical research · 1992Review
- Expression of a genomic clone encoding a brain potassium channel in mammalian cells using lipofection.European biophysics journal : EBJ · 1992Article
- Use of toxins to study potassium channels.Journal of bioenergetics and biomembranes · 1991Review
- Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
A recombinant vaccinia virus containing a Drosophila potassium channel (Shaker H4) cDNA was constructed by homologous recombination between wild-type vaccinia virus DNA and a transfer plasmid. The new virus was used to infect four types of mammalian cells in culture. Electrophysiological recording 24-72 hr after infection revealed the expression of voltage-gated transient potassium channels in all four cell types. The properties of the induced currents were identical to those previously observed following injection of the Shaker H4 transcript into oocytes. Vaccinia promises to be an effective vehicle for the heterologous expression of transmembrane ion channels in a variety of cell types.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.