ArticleProceedings of the National Academy of Sciences of the United States of America2014
Arabidopsis ABCG14 is essential for the root-to-shoot translocation of cytokinin.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 148 papers.
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148 citing papers in PubMed, 327 citations in OpenAlex.
- Towards an integrated molecular understanding of plant hormones.Journal of integrative plant biology · 2026Review
- Cytokinin receptor AHK3 influences leaf size by modulating trans-zeatin-type cytokinin levels in xylem.Plant & cell physiology · 2026Article
- OsPUP1 Modulates Cytokinin Distribution and Antioxidant Defense to Regulate Heat Stress Tolerance in Rice.Antioxidants (Basel, Switzerland) · 2026Article
- Evolutionary shifts in plant adaptation mediated by phytohormones.Plant communications · 2026Review
- Evolutionary Repurposing of Cytokinin Signaling in Plant Development and Symbiosis.Plants (Basel, Switzerland) · 2026Review
- Article
- Cytokinin availability and chloroplast functional lifetime in senescing leaves.Frontiers in plant science · 2026Review
- Integrated metabolomics, PacBio SMRT, and Illumina sequencing analyses provide insights into molecular profiles associated with radial trunk growth in Chinese fir (Frontiers in plant science · 2026Article
- Coordinated Auxin-Cytokinin-Nitrogen Signaling Orchestrates Root Suckering in Populus.International journal of molecular sciences · 2025Article
- Membrane transport of root-borne trans-zeatin riboside maintains the cytokinin homeostasis in shoots.Journal of experimental botany · 2025Article
- When two become one: perceptual completion in pea plants.Plant signaling & behavior · 2025Article
- Fluctuations in nitrate availability impact cytokinin biosynthesis through histone modifications of IPT3 in Arabidopsis roots for growth acclimation.Plant communications · 2025Article
- Hormone Fluctuation and Gene Expression During Early Stages of the Hickory Grafting Process.Plants (Basel, Switzerland) · 2025Article
- Root-derived cytokinin regulates Arabidopsis flowering time through components of the age pathway.Plant physiology · 2025Article
- Decoding Long-Distance Communication Under Mineral Stress: Advances in Vascular Signalling and Molecular Tools for Plant Resilience.Plant, cell & environment · 2025Review
- Five unaddressed questions about cytokinin biosynthesis.Journal of experimental botany · 2025Review
- Structural basis of cytokinin transport by the Arabidopsis AZG2.Nature communications · 2025Article
- Lights, location, action: shade avoidance signalling over spatial scales.Journal of experimental botany · 2025Review
- Trichostatin A promotes de novo shoot regeneration from Arabidopsis root explants via a cytokinin related pathway.Scientific reports · 2025Article
- Plant hormones and membrane transporters: integrating nutrient uptake, ion homeostasis, and stress responses through hormonal cross-talk.Frontiers in plant science · 2025Review
88 more citing papers are in PubMed but not listed here.
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Authors and funding
13 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cytokinins are phytohormones that induce cytokinesis and are essential for diverse developmental and physiological processes in plants. Cytokinins of the trans-zeatin type are mainly synthesized in root vasculature and transported to the shoot, where they regulate shoot growth. However, the mechanism of long-distance transport of cytokinin was hitherto unknown. Here, we report that the Arabidopsis ATP-binding cassette (ABC) transporter subfamily G14 (AtABCG14) is mainly expressed in roots and plays a major role in delivering cytokinins to the shoot. Loss of AtABCG14 expression resulted in severe shoot growth retardation, which was rescued by exogenous trans-zeatin application. Cytokinin content was decreased in the shoots of atabcg14 plants and increased in the roots, with consistent changes in the expression of cytokinin-responsive genes. Grafting of atabcg14 scions onto wild-type rootstocks restored shoot growth, whereas wild-type scions grafted onto atabcg14 rootstocks exhibited shoot growth retardation similar to that of atabcg14. Cytokinin concentrations in the xylem are reduced by ∼90% in the atabcg14 mutant. These results indicate that AtABCG14 is crucial for the translocation of cytokinin to the shoot. Our results provide molecular evidence for the long-distance transport of cytokinin and show that this transport is necessary for normal shoot development.
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