ArticleProceedings of the National Academy of Sciences of the United States of America2014
Multivariate analysis reveals genetic associations of the resting default mode network in psychotic bipolar disorder and schizophrenia.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 146 papers, 5 of them syntheses that pooled it.
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Who cites it
146 citing papers in PubMed, 5 syntheses or guidelines pooled it, 260 citations in OpenAlex.
- The hierarchical taxonomy of psychopathology and the search for neurobiological substrates of mental illness: A systematic review and roadmap for future research.Journal of psychopathology and clinical science · 2024Pooled it
- Default Mode Network Modulation by Psychedelics: A Systematic Review.The international journal of neuropsychopharmacology · 2023Pooled it
- Altered functional activity in bipolar disorder: A comprehensive review from a large-scale network perspective.Brain and behavior · 2021Pooled it
- Systematic Review of Functional MRI Applications for Psychiatric Disease Subtyping.Frontiers in psychiatry · 2021Pooled it
- Neuroanatomical phenotypes in mental illness: identifying convergent and divergent cortical phenotypes across autism, ADHD and schizophrenia.Journal of psychiatry & neuroscience : JPN · 2018Pooled it
- Effect of single dose N-acetylcysteine administration on resting state functional connectivity in schizophrenia.Psychopharmacology · 2020Trial
- Adding Sarcosine to Antipsychotic Treatment in Patients with Stable Schizophrenia Changes the Concentrations of Neuronal and Glial Metabolites in the Left Dorsolateral Prefrontal Cortex.International journal of molecular sciences · 2015Trial
- Spatiotemporal complexity in the psychotic brain.Molecular psychiatry · 2026Article
- Microstructural Disruption of the Forceps Minor in Schizophrenia: A Potential Clinical Imaging Biomarker Using Translational DTI.bioRxiv : the preprint server for biology · 2026Article
- Brain Age Disparities in Psychosis Across DSM Diagnoses and B-SNIP Biotypes.Schizophrenia bulletin · 2026Article
- The (un-)Social Brain in Isolation.Physiological research · 2025Review
- Mapping neurophysiological and molecular profiles of heterogeneity and homogeneity in schizophrenia-bipolar disorder.Science advances · 2025Article
- Higher-Order Triadic Interactions: Insights Into the Multiscale Network Organization in Schizophrenia.Human brain mapping · 2025Article
- LINKING BRAIN ENTROPY TO MOLECULAR AND CELLULAR ARCHITECTURE IN PSYCHOSIS.bioRxiv : the preprint server for biology · 2025Article
- Network localization of genetic risk for schizophrenia and bipolar disorder.Psychological medicine · 2025Article
- Reduced glymphatic clearance in early psychosis.Molecular psychiatry · 2025Article
- Neural fingerprints of data driven cognitive subtypes across the psychosis spectrum: a B-SNIP study.Translational psychiatry · 2025Article
- Multimodal integration of homotopic connectivity and transcriptomic signatures in major depressive disorder with sleep disorder comorbidity.BMC psychiatry · 2025Article
- Genetic analysis of psychosis Biotypes: shared Ancestry-adjusted polygenic risk and unique genomic associations.Molecular psychiatry · 2025Article
- Advances in the fMRI analysis of the default mode network: a review.Brain structure & function · 2024Review
86 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
16 authors at 8 institutions in 1 country.
Funding
Abstract
The brain's default mode network (DMN) is highly heritable and is compromised in a variety of psychiatric disorders. However, genetic control over the DMN in schizophrenia (SZ) and psychotic bipolar disorder (PBP) is largely unknown. Study subjects (n = 1,305) underwent a resting-state functional MRI scan and were analyzed by a two-stage approach. The initial analysis used independent component analysis (ICA) in 324 healthy controls, 296 SZ probands, 300 PBP probands, 179 unaffected first-degree relatives of SZ probands (SZREL), and 206 unaffected first-degree relatives of PBP probands to identify DMNs and to test their biomarker and/or endophenotype status. A subset of controls and probands (n = 549) then was subjected to a parallel ICA (para-ICA) to identify imaging-genetic relationships. ICA identified three DMNs. Hypo-connectivity was observed in both patient groups in all DMNs. Similar patterns observed in SZREL were restricted to only one network. DMN connectivity also correlated with several symptom measures. Para-ICA identified five sub-DMNs that were significantly associated with five different genetic networks. Several top-ranking SNPs across these networks belonged to previously identified, well-known psychosis/mood disorder genes. Global enrichment analyses revealed processes including NMDA-related long-term potentiation, PKA, immune response signaling, axon guidance, and synaptogenesis that significantly influenced DMN modulation in psychoses. In summary, we observed both unique and shared impairments in functional connectivity across the SZ and PBP cohorts; these impairments were selectively familial only for SZREL. Genes regulating specific neurodevelopment/transmission processes primarily mediated DMN disconnectivity. The study thus identifies biological pathways related to a widely researched quantitative trait that might suggest novel, targeted drug treatments for these diseases.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.