ArticleInfection and immunity2014
The Salmonella effector SteA contributes to the control of membrane dynamics of Salmonella-containing vacuoles.
Article in Infection and immunity, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed.
- The Manipulation of Host Cells byInternational journal of molecular sciences · 2026Review
- Structure and function of Salmonella inner membrane.Archives of microbiology · 2026Review
- Article
- The interplay betweenCell insight · 2025Review
- Review
- Roles of SPI-2 T3SS effectors in virulence ofFrontiers in veterinary science · 2025Article
- Infection biology ofEcoSal Plus · 2024Review
- Functional Divergence of the ParalogInternational journal of molecular sciences · 2024Review
- Effector Translocation Assay: Differential Solubilization.Methods in molecular biology (Clifton, N.J.) · 2024Article
- Manipulation of host immune defenses by effector proteins delivered from multiple secretion systems ofFrontiers in immunology · 2023Review
- Endomembrane remodeling and dynamics inMicrobial cell (Graz, Austria) · 2022Review
- Recent Advancements in Tracking Bacterial Effector Protein Translocation.Microorganisms · 2022Review
- Discovery and characterization of a new genotype ofFrontiers in microbiology · 2022Article
- Quantitative proteomic screen identifies annexin A2 as a host target for Salmonella pathogenicity island-2 effectors SopD2 and PipB2.Scientific reports · 2021Article
- Systematic reconstruction of an effector-gene network reveals determinants of Salmonella cellular and tissue tropism.Cell host & microbe · 2021Article
- SAC1 regulates autophagosomal phosphatidylinositol-4-phosphate for xenophagy-directed bacterial clearance.Cell reports · 2021Article
- Review
- Article
- The Role of the Type III Secretion System in the Intracellular Lifestyle of Enteric Pathogens.Microbiology spectrum · 2019Review
- Non-typhoidal Salmonella blood stream infection in Kuwait: Clinical and microbiological characteristics.PLoS neglected tropical diseases · 2019Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Salmonella enterica serovar Typhimurium is a bacterial pathogen causing gastroenteritis in humans and a typhoid-like systemic disease in mice. S. Typhimurium virulence is related to its capacity to multiply intracellularly within a membrane-bound compartment, the Salmonella-containing vacuole (SCV), and depends on type III secretion systems that deliver bacterial effector proteins into host cells. Here, we analyzed the cellular function of the Salmonella effector SteA. We show that, compared to cells infected by wild-type S. Typhimurium, cells infected by ΔsteA mutant bacteria displayed fewer Salmonella-induced filaments (SIFs), an increased clustering of SCVs, and morphologically abnormal vacuoles containing more than one bacterium. The increased clustering of SCVs and the appearance of vacuoles containing more than one bacterium were suppressed by inhibition of the activity of the microtubule motor dynein or kinesin-1. Clustering and positioning of SCVs are controlled by the effectors SseF and SseG, possibly by helping to maintain a balanced activity of microtubule motors on the bacterial vacuoles. Deletion of steA in S. Typhimurium ΔsseF or ΔsseG mutants revealed that SteA contributes to the characteristic scattered distribution of ΔsseF or ΔsseG mutant SCVs in infected cells. Overall, this shows that SteA participates in the control of SCV membrane dynamics. Moreover, it indicates that SteA is functionally linked to SseF and SseG and suggests that it might contribute directly or indirectly to the regulation of microtubule motors on the bacterial vacuoles.
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