ReviewCroatian medical journal2014
Markers for sepsis diagnosis in the forensic setting: state of the art.
Review in Croatian medical journal, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Association between IL-6 polymorphisms and sepsis.Innate immunity · 2019Pooled it
- Host genetics and susceptibility to congenital and childhood cytomegalovirus infection: a systematic review.Croatian medical journal · 2016Pooled it
- Association between IL-6-174G/C polymorphism and the risk of sepsis and mortality: a systematic review and meta-analysis.PloS one · 2015Pooled it
- Postmortem Blood Procalcitonin (PCT) for identifying sepsis as a cause of death: a systematic review and meta-analysis.International journal of legal medicine · 2026Review
- Article
- Exploratory Analysis of TLR2, TLR4, Interleukin 6 and Interleukin 10 Gene Polymorphisms in Relation to Clinical Early-Onset Sepsis in Preterm Neonates: A Single-Center Study.Life (Basel, Switzerland) · 2026Article
- Leaky Gut Biomarkers as Predictors of Depression and Suicidal Risk: A Systematic Review and Meta-Analysis.Diagnostics (Basel, Switzerland) · 2025Review
- Inflammatory Markers Significantly Increased in Patients Treated with Obinotuzumab for Lymphoproliferative Diseases.Journal of clinical medicine · 2024Article
- A meta-summary and bioinformatic analysis identified interleukin 6 as a master regulator of COVID-19 severity biomarkers.Cytokine · 2022Article
- Post-Mortem Microbiology: Retrospective Analysis of Infections Caused byPathogens (Basel, Switzerland) · 2022Article
- Autopsy Findings and Inflammatory Markers in SARS-CoV-2: A Single-Center Experience.International journal of general medicine · 2022Article
- Post-Mortem Investigations for the Diagnosis of Sepsis: A Review of Literature.Diagnostics (Basel, Switzerland) · 2020Review
- Article
- Evaluation of the distribution of nicotine intravenous injection: an adult autopsy case report with a review of literature.International journal of legal medicine · 2020Review
- Cytokine and Chemokine Profiling in Cats With Sepsis and Septic Shock.Frontiers in veterinary science · 2020Article
- Sepsis and Nosocomial Infections: The Role of Medico-Legal Experts in Italy.Antibiotics (Basel, Switzerland) · 2019Review
- Post-mortem in situ stability of serum markers of cerebral damage and acute phase response.International journal of legal medicine · 2019Article
- Analysis on sarcoglycans expression as markers of septic cardiomyopathy in sepsis-related death.International journal of legal medicine · 2018Observational
- Effect of intra-abdominally administered mesalazine (5-aminosalicylic acid) in experimental peritonitis.Northern clinics of Istanbul · 2018Article
- Soluble TREM-1 Serum Level can Early Predict Mortality of Patients with Sepsis, Severe Sepsis and Septic Shock.Archivum immunologiae et therapiae experimentalis · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Reliable diagnoses of sepsis remain challenging in forensic pathology routine despite improved methods of sample collection and extensive biochemical and immunohistochemical investigations. Macroscopic findings may be elusive and have an infectious or non-infectious origin. Blood culture results can be difficult to interpret due to postmortem contamination or bacterial translocation. Lastly, peripheral and cardiac blood may be unavailable during autopsy. Procalcitonin, C-reactive protein, and interleukin-6 can be measured in biological fluids collected during autopsy and may be used as in clinical practice for diagnostic purposes. However, concentrations of these parameters may be increased due to etiologies other than bacterial infections, indicating that a combination of biomarkers could more effectively discriminate non-infectious from infectious inflammations. In this article, we propose a review of the literature pertaining to the diagnostic performance of classical and novel biomarkers of inflammation and bacterial infection in the forensic setting.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.