ArticleAnticancer research2014
Bone morphogenetic protein-focused strategies to induce cytotoxicity in lung cancer cells.
Article in Anticancer research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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Who cites it
19 citing papers in PubMed, 27 citations in OpenAlex.
- Mechanisms of Bone Morphogenetic Protein 2 in Respiratory Diseases.Current allergy and asthma reports · 2024Review
- BMP2 promotes lung adenocarcinoma metastasis through BMP receptor 2-mediated SMAD1/5 activation.Scientific reports · 2022Article
- Circular RNA FLNA acts as a sponge of miR-486-3p in promoting lung cancer progression via regulating XRCC1 and CYP1A1.Cancer gene therapy · 2022Article
- miR-486 Promotes the Invasion and Cell Cycle Progression of Ovarian Cancer Cells by Targeting CADM1.Analytical cellular pathology (Amsterdam) · 2021Article
- MiR-486-3p inhibits the proliferation, migration and invasion of retinoblastoma cells by targeting ECM1.Bioscience reports · 2020Article
- Review
- Inhibition of bone morphogenetic protein signaling reduces viability, growth and migratory potential of non-small cell lung carcinoma cells.Journal of cancer research and clinical oncology · 2019Article
- MicroRNA-486-3p functions as a tumor suppressor in oral cancer by targeting DDR1.Journal of experimental & clinical cancer research : CR · 2019Article
- Identification of nine microRNAs as potential biomarkers for lung adenocarcinoma.FEBS open bio · 2019Article
- BMP4 Upregulation Is Associated with Acquired Drug Resistance and Fatty Acid Metabolism in EGFR-Mutant Non-Small-Cell Lung Cancer Cells.Molecular therapy. Nucleic acids · 2018Article
- Structural basis for the potent and selective binding of LDN-212854 to the BMP receptor kinase ALK2.Bone · 2018Review
- The Genetic Regulation of Aortic Valve Development and Calcific Disease.Frontiers in cardiovascular medicine · 2018Review
- Characterization of new bone morphogenetic protein (Bmp)-2 regulatory alleles.Genesis (New York, N.Y. : 2000) · 2017Article
- Emerging roles of the bone morphogenetic protein pathway in cancer: potential therapeutic target for kinase inhibition.Biochemical Society transactions · 2016Review
- Sjögren's syndrome-associated microRNAs in CD14(+) monocytes unveils targeted TGFβ signaling.Arthritis research & therapy · 2016Article
- Competing Repressive Factors Control Bone Morphogenetic Protein 2 (BMP2) in Mesenchymal Cells.Journal of cellular biochemistry · 2016Article
- Turning Bone Morphogenetic Protein 2 (BMP2) on and off in Mesenchymal Cells.Journal of cellular biochemistry · 2015Review
- A role for BMP-induced homeobox gene MIXL1 in acute myelogenous leukemia and identification of type I BMP receptor as a potential target for therapy.Oncotarget · 2014Article
- Calcific aortic valve disease: a consensus summary from the Alliance of Investigators on Calcific Aortic Valve Disease.Arteriosclerosis, thrombosis, and vascular biology · 2014Review
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
backgroundHigh bone morphogenetic protein (BMP)-2 expression in lung carcinoma correlates with poor patient prognosis. The present study explored strategies to repress BMP signaling. MATERIALS AND
methodsThe cytotoxicity of BMP2-knockdown, dorsomorphin derivatives, and microRNAs was tested in transformed and non-transformed lung cells. Microarray analyses of 1,145 microRNAs in A549 lung adenocarcinoma cells and two other transformed lung cell types relative to BEAS-2B bronchial epithelial cells were performed.
resultsReduced BMP2 synthesis inhibited A549 cell growth. The dorsomorphin derivative LDN-193189, but not DMH1 or DMH4, was strongly cytotoxic towards A549 cells, but not towards BEAS-2B cells. Microarray analysis revealed that 106 miRNAs were down-regulated and 69 miRNAs were up-regulated in the three transformed lines. Three down-regulated miRNAs, hsa-mir-34b, hsa-mir-34c-3p, and hsa-miR-486-3p, repressed a BMP2 reporter gene and were cytotoxic in A549 cells, but not towards BEAS-2B cells.
conclusionThe observed cytotoxicity suggests that reducing BMP signaling is a useful line of attack for therapy of lung cancer.
Indexed as
Identifiers
24778011PMC4791537W2116137601What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.