ArticleAnnals of neurology2014
Linking MRI postprocessing with magnetic source imaging in MRI-negative epilepsy.
Article in Annals of neurology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 1 of them a synthesis that pooled it.
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Who cites it
35 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Accuracy of Interictal and Ictal Electric and Magnetic Source Imaging: A Systematic Review and Meta-Analysis.Frontiers in neurology · 2019Pooled it
- Comparison of volume- and surface-based magnetic resonance imaging morphometry algorithms in the detection of focal cortical dysplasia.Epilepsia · 2026Article
- Sleep magnetoencephalography enhances detection and source imaging of seizures and fast oscillations in focal cortical dysplasia.Epilepsia · 2026Article
- MRI Interpretation Errors in Adult Patients with Medically Refractory Epilepsy.AJNR. American journal of neuroradiology · 2025Observational
- Potential role of MELD and MAP18 in patients with structural temporal lobe epilepsy.Neuroradiology · 2025Article
- Combined MRI morphometry and source imaging guide placement of stereo-EEG electrodes in focal epilepsy with subtle or absent lesions.Frontiers in neurology · 2025Article
- MEG in MRI-Negative Patients with Focal Epilepsy.Journal of clinical medicine · 2024Review
- Neurofilament Light Chain Levels Interact with Neurodegenerative Patterns and Motor Neuron Dysfunction in Amyotrophic Lateral Sclerosis.AJNR. American journal of neuroradiology · 2024Article
- Multimodal non-invasive evaluation in MRI-negative epilepsy patients.Epilepsia open · 2024Article
- Diagnostic Accuracy of Epilepsy-dedicated MRI with Post-processing.Clinical neuroradiology · 2023Article
- Lesion Detection Through MRI Postprocessing in Pathology-Proven Focal Cortical Dysplasia: Experience at a Single Institution in the Republic of Korea.Journal of clinical neurology (Seoul, Korea) · 2023Article
- Multimodal imaging-based diagnostic approach for MRI-negative posterior cortex epilepsy.Therapeutic advances in neurological disorders · 2023Article
- Clinical and Surgical Approach for Cerebral Cortical Dysplasia.Advances and technical standards in neurosurgery · 2023Article
- Article
- "Within a minute" detection of focal cortical dysplasia.Neuroradiology · 2022Article
- Morphometric analysis program: Detection of epileptic foci in young children using an adult normative database: Initial experience.Epilepsia open · 2021Article
- Fluid and White Matter Suppression Imaging and Voxel-Based Morphometric Analysis in Conventional Magnetic Resonance Imaging-Negative Epilepsy.Frontiers in neurology · 2021Article
- Response to antiseizure medications in epileptic patients with malformation of cortical development.Therapeutic advances in neurological disorders · 2021Article
- Practical Fundamentals of Clinical MEG Interpretation in Epilepsy.Frontiers in neurology · 2021Review
- Value of 7T MRI and post-processing in patients with nonlesional 3T MRI undergoing epilepsy presurgical evaluation.Epilepsia · 2020Article
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Authors and funding
13 authors.
Funding
Abstract
objectiveMRI-negative (MRI-) pharmacoresistant focal epilepsy (PFE) patients are most challenging for epilepsy surgical management. This study utilizes a voxel-based MRI postprocessing technique, implemented using a morphometric analysis program (MAP), aiming to facilitate detection of subtle focal cortical dysplasia (FCD) in MRI- patients. Furthermore, the study examines the concordance between MAP-identified regions and localization from magnetic source imaging (MSI).
methodsIncluded in this retrospective study were 25 MRI- surgical patients. MAP was performed on T1-weighted MRI, with comparison to a normal database. The pertinence of MAP+ areas was confirmed by MSI, surgical outcome and pathology. Analyses of MAP and MSI were performed blindly from patients' clinical information and independently from each other.
resultsThe detection rate of subtle changes by MAP was 48% (12/25). Once MAP+ areas were resected, patients were more likely to be seizure-free (p=0.02). There were no false positives in the 25 age-matched normal controls. Seven patients had a concordant MSI correlate. Patients in whom a concordant area was identified by both MAP and MSI had a significantly higher chance of achieving a seizure-free outcome following complete resection of this area (p=0.008). In the 9 resected MAP+ areas, pathology revealed FCD type IA in 7 and type IIB in 2.
interpretationMAP shows promise in identifying subtle FCD abnormalities and increasing the diagnostic yield of conventional MRI visual analysis in presurgical evaluation of PFE. Concordant MRI postprocessing and MSI analyses may lead to the noninvasive identification of a structurally and electrically abnormal subtle lesion that can be surgically targeted.
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