ArticleCirculation. Cardiovascular imaging2014
In vivo molecular imaging of thrombosis and thrombolysis using a fibrin-binding positron emission tomographic probe.
Article in Circulation. Cardiovascular imaging, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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26 citing papers in PubMed, 47 citations in OpenAlex.
- Noninvasive Thrombus Imaging in Patients With Ischemic Stroke.Circulation · 2026Observational
- Unveiling the procoagulant state in Alzheimer's disease: A novel PET imaging strategy.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Ultrasound-actuated platelet mimetic nanomotors enable targeted piezocatalytic ROS storm for precision thrombolysis.Journal of nanobiotechnology · 2025Article
- Delivery of a fibrin-binding hemostatic polymer ameliorates neurovascular damage and neural tissue loss after traumatic brain injury.Science advances · 2025Article
- First-in-human Evaluation of Safety and Dosimetry of [Molecular imaging and biology · 2025Article
- Dosimetry of [medRxiv : the preprint server for health sciences · 2024Article
- Detection and Characterization of Thrombosis in Humans Using Fibrin-Targeted Positron Emission Tomography and Magnetic Resonance.JACC. Cardiovascular imaging · 2022Article
- Imaging High-Risk Atherothrombosis Using a Novel Fibrin-Binding Positron Emission Tomography Probe.Stroke · 2022Article
- A fibrin targeted molecular imaging evaluation of microvascular no-reflow in acute ischemic stroke.Brain and behavior · 2022Article
- Multi-Scale Imaging of Vascular Pathologies in Cardiovascular Disease.Frontiers in medicine · 2021Review
- Non-invasive in vivo imaging of acute thrombosis: development of a novel factor XIIIa radiotracer.European heart journal. Cardiovascular Imaging · 2020Article
- Radionuclide Imaging of Atherothrombotic Diseases.Current cardiovascular imaging reports · 2019Article
- Synthesis and Preclinical Evaluation of the Fibrin-Binding Cyclic PeptideContrast media & molecular imaging · 2019Article
- Peptide-based fibrin-targeting probes for thrombus imaging.Dalton transactions (Cambridge, England : 2003) · 2017Review
- FeInternational journal of nanomedicine · 2017Article
- Brain Vascular Imaging Techniques.International journal of molecular sciences · 2016Review
- Direct Thrombus Imaging in Stroke.Journal of stroke · 2016Review
- Academic-industry Collaborations in Translational Stroke Research.Translational stroke research · 2016Article
- Assessment of Venous Thrombosis in Animal Models.Arteriosclerosis, thrombosis, and vascular biology · 2016Review
- A Manganese Alternative to Gadolinium for MRI Contrast.Journal of the American Chemical Society · 2015Article
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10 authors at 1 institution in 1 country.
Funding
Abstract
backgroundFibrin is a major component of arterial and venous thrombi and represents an ideal candidate for molecular imaging of thrombosis. Here, we describe imaging properties and target uptake of a new fibrin-specific positron emission tomographic probe for thrombus detection and therapy monitoring in 2 rat thrombosis models. METHODS AND
resultsThe fibrin-binding probe FBP7 was synthesized by conjugation of a known short cyclic peptide to a cross-bridged chelator (CB-TE2A), followed by labeling with copper-64. Adult male Wistar rats (n=26) underwent either carotid crush injury (mural thrombosis model) or embolic stroke (occlusive thrombosis model) followed by recombinant tissue-type plasminogen activator treatment (10 mg/kg, IV). FBP7 detected thrombus location in both animal models with a high positron emission tomographic target-to-background ratio that increased over time (>5-fold at 30-90 minutes, >15-fold at 240-285 minutes). In the carotid crush injury animals, biodistribution analysis confirmed high probe uptake in the thrombotic artery (≈0.5%ID/g; >5-fold greater than blood and other tissues of the head and thorax). Similar results were obtained from ex vivo autoradiography of the ipsilateral versus contralateral carotid arteries. In embolic stroke animals, positron emission tomographic-computed tomographic imaging localized the clot in the internal carotid/middle cerebral artery segment of all rats. Time-dependent reduction of activity at the level of the thrombus was detected in recombinant tissue-type plasminogen activator-treated rats but not in vehicle-injected animals. Brain autoradiography confirmed clot dissolution in recombinant tissue-type plasminogen activator-treated animals, but enduring high thrombus activity in control rats.
conclusionsWe demonstrated that FBP7 is suitable for molecular imaging of thrombosis and thrombolysis in vivo and represents a promising candidate for bench-to-bedside translation.
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