ArticleGlycoconjugate journal2014
An α-glucan isolated from root of Isatis Indigotica, its structure and adjuvant activity.
Article in Glycoconjugate journal, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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9 citing papers in PubMed, 21 citations in OpenAlex.
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- Structural Elucidation of a Glucan fromMarine drugs · 2023Article
- Immunomodulatory effects ofExperimental and therapeutic medicine · 2021Article
- Polysaccharide PCP-I isolated fromHuman vaccines & immunotherapeutics · 2020Article
- The complete chloroplast genome sequence of the medicinal and economic plant woadMitochondrial DNA. Part B, Resources · 2017Article
- Isatis indigotica root polysaccharides as adjuvants for an inactivated rabies virus vaccine.International journal of biological macromolecules · 2016Article
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Authors and funding
11 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The root of Isatis indigotica is a traditional Chinese herbal medicine. An α-glucan (IIP-A-1) was firstly isolated from the roots. In this study we elucidated the chemical structure of IIP-A-1 and determined its adjuvant activity by co-immunizing mice with H1N1 influenza virus split and recombinant hepatitis B surface antigen (HBsAg), respectively. The polysaccharide was pretreated with periodate oxidation, Smith degradation and methylation in order to analyze its structure using GC, HPGPC, FT-IR, NMR and GC-MS. The adjuvant effect was evaluated by determining the antibody titers of serum against H1N1 influenza and HBsAg using ELISA. The proliferation and TNF-α secretion of macrophages administrated with different dose of IIP-A-1 were measured in vitro. The results of this study revealed that IIP-A-1 was an α-glucan with the molecular weight of 3,600 Da. The backbone was α-(1 → 4)-D-glucan with (1 → 6) branch chain. The α-glucan could significantly enhance the immune response of mice immunized with H1N1 influenza or HBsAg in vivo and exert good dose-dependent effects on the proliferation and the TNF-α secretion of macrophages in vitro. These results supported that IIP-A-1 was expected to be an efficacious adjuvant candidate for prophylactic and therapeutic vaccines.
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