Evidence map›Paper›PMID 24777644›Full record

ReviewInvestigative ophthalmology & visual science2014

Drug and gene delivery to the back of the eye: from bench to bedside.

Cheryl L Rowe-Rendleman, Shelley A Durazo, Uday B Kompella, Kay D Rittenhouse, Adriana Di Polo, Alan L Weiner, Hans E Grossniklaus, Muna I Naash, Alfred S Lewin, Alan Horsager and 1 more

Abstract readReview
In one paragraph

Review in Investigative ophthalmology & visual science, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 62 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
62citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

62 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Review
  4. Review
  5. Nanotherapy for Neural Retinal Regeneration.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Review
  6. A Model of the Mechanisms Underpinning Unconventional Aqueous Humor Outflow.Investigative ophthalmology & visual science · 2025
    Article
  7. Article
  8. Review
  9. Review
  10. Article
  11. Article
  12. Review
  13. Article
  14. Article
  15. Review
  16. Ocular Safety and Toxicokinetics of Bevacizumab-bvzr (Zirabev), a Bevacizumab Biosimilar, Administered to Cynomolgus Monkeys by Intravitreal Injection.Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics · 2023
    Article
  17. Article
  18. Article
  19. Review
  20. Review

2 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Cheryl L Rowe-RendlemanOmar Consulting Group, LLC, Princeton Junction, New Jersey, United States.
Shelley A Durazo
Uday B Kompella
Kay D Rittenhouse
Adriana Di Polo
Alan L Weiner
Hans E Grossniklaus
Muna I Naash
Alfred S Lewin
Alan Horsager
Henry F Edelhauser

Funding

P30-Core Grant for Vision Research Core CP30EY006360 · NEI · EMORY UNIVERSITY · PI NICKERSON, JOHN M · 1986 to 2025
$15.3M
Compacted DNA Nanoparticles for Ocular TherapyR01EY018656 · NEI · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI AL-UBAIDI, MUAYYAD R, NAASH, MUNA I. · 2008 to 2021
$5.6M
DNA nanoparticle formulations for optimal ocular gene deliveryR01EY022778 · NEI · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI NAASH, MUNA I. · 2012 to 2014
$1.3M
Drug and Gene Delivery to the Back of the Eye: From Bench to BedsideR13EY021956 · NEI · UNIVERSITY OF COLORADO DENVER · PI KOMPELLA, UDAY B · 2011 to 2011
$34k
NEI NIH HHS 1R13EY021956-01NEI NIH HHS P30 EY006360NEI NIH HHS R01 EY018656NEI NIH HHS R01 EY022778NEI NIH HHS R13 EY021956
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Gene Transfer TechniquesDrug Delivery SystemsGenetic TherapyHumansPharmaceutical PreparationsRetinal DiseasesPharmaceutical Preparationsdrug deliverygene therapynanoparticleretinatranslational medicine

Identifiers

PMID24777644
PMCPMC4004426

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.