ArticleCancer immunology, immunotherapy : CII2014
Altered chemokine production and accumulation of regulatory T cells in intestinal adenomas of APC(Min/+) mice.
Article in Cancer immunology, immunotherapy : CII, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 40 citations in OpenAlex.
- The Immune Environment in Colorectal Adenoma: A Systematic Review.Biomedicines · 2025Review
- Jianpi Lishi Jiedu Decoction (JLJD) Inhibit Th17 Cell Differentiation via the Jak/Stat3/RORγt Pathway in Colorectal Adenomas.Journal of inflammation research · 2025Article
- Regulatory T Cells Play a Role in Determining the Tumourigenicity of the Intestinal Stem Cell Niche.Gastro hep advances · 2025Review
- Identification of biomarkers for the diagnosis in colorectal polyps and metabolic dysfunction-associated steatohepatitis (MASH) by bioinformatics analysis and machine learning.Scientific reports · 2024Article
- Advancing translational research for colorectal immuno-oncology.British journal of cancer · 2023Review
- Molecular Pathways of Carcinogenesis in Familial Adenomatous Polyposis.International journal of molecular sciences · 2023Review
- Altered Mucosal Immune-Microbiota Interactions in Familial Adenomatous Polyposis.Clinical and translational gastroenterology · 2022Article
- De novo assembly provides new insights into the evolution of Elaeagnus angustifolia L.Plant methods · 2022Article
- Immune Microenvironment: New Insight for Familial Adenomatous Polyposis.Frontiers in oncology · 2021Review
- YYFZBJS ameliorates colorectal cancer progression in ApcCell communication and signaling : CCS · 2020Article
- Review
- Regulatory T cells specifically suppress conventional CD8αβ T cells in intestinal tumors of APCCancer immunology, immunotherapy : CII · 2020Article
- Coordinating Cytoskeleton and Molecular Traffic in T Cell Migration, Activation, and Effector Functions.Frontiers in cell and developmental biology · 2020Review
- Helicobacter pylori infection associated with an increased risk of colorectal adenomatous polyps in the Chinese population.BMC gastroenterology · 2019Article
- Increased Incidence of Colon Tumors in AOM-TreatedFrontiers in oncology · 2019Article
- Regulatory T cells control endothelial chemokine production and migration of T cells into intestinal tumors of APCCancer immunology, immunotherapy : CII · 2018Article
- Evolving notions on immune response in colorectal cancer and their implications for biomarker development.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2018Review
- Colorectal cancer prevention: Immune modulation taking the stage.Biochimica et biophysica acta. Reviews on cancer · 2018Review
- Underlying Causes and Therapeutic Targeting of the Inflammatory Tumor Microenvironment.Frontiers in cell and developmental biology · 2018Review
- Chronic Trichuris muris infection causes neoplastic change in the intestine and exacerbates tumour formation in APC min/+ mice.PLoS neglected tropical diseases · 2017Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Tumor progression in the colon moves from aberrant crypt foci to adenomatous polyps to invasive carcinomas. The composition of the tumor-infiltrating leukocyte population affects the ability of the immune system to fight the tumor. T cell infiltration into colorectal adenocarcinomas, particularly T helper 1 (Th1) type T cells as well as increased regulatory T cell (Treg) frequencies, is correlated with improved prognosis. However, whether Th1 cells and Tregs are already present at the adenoma stage is not known. In this study, the APC(Min/+) mouse model of intestinal adenomatous polyposis was used to investigate tumor-associated lymphocyte subsets and the mechanisms of their accumulation into gastrointestinal adenomas. Compared to unaffected tissue, adenomas accumulated CD4(+)FoxP3(+) putative Treg in parallel with lower frequencies of conventional T cells and B cells. The accumulation of Treg was also observed in human adenomatous polyps. Despite high Treg numbers, the function of conventional T cells present in the APC(Min/+) adenomas was not different from those in the unaffected tissue. Adenomas displayed an altered chemokine balance, with higher CCL17 and lower CXCL11 and CCL25 expression than in the unaffected tissue. In parallel, CXCR3(+) Tregs were largely absent from adenomas. The data indicate that already in early stages of tumor development, the balance of lymphocyte-recruiting chemokines is altered possibly contributing to the observed shift toward higher frequencies of Treg.
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