ArticleCognitive, affective & behavioral neuroscience2014
Weak ventral striatal responses to monetary outcomes predict an unwillingness to resist cigarette smoking.
Article in Cognitive, affective & behavioral neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
30 citing papers in PubMed, 47 citations in OpenAlex.
- Pain characteristics and nicotine deprivation as predictors of performance during a laboratory paradigm of smoking cessation.Psychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors · 2020Trial
- Neural Signatures of Cognitive Flexibility and Reward Sensitivity Following Nicotinic Receptor Stimulation in Dependent Smokers: A Randomized Trial.JAMA psychiatry · 2017Trial
- An Exploratory Study of an fMRI Reward-Learning Paradigm in Developing Adolescents.Children (Basel, Switzerland) · 2026Article
- Positive Emotion Regulation in Addiction: A New Frontier for Recovery Science.Current addiction reports · 2026Review
- A novel human laboratory alcohol self-administration paradigm for medication screening: Modeling the ability to resist drinking and heavy drinking.Drug and alcohol dependence reports · 2022Article
- How laboratory studies of cigarette craving can inform the experimental alcohol craving literature.Alcoholism, clinical and experimental research · 2022Review
- The feasibility of an in-scanner smoking lapse paradigm to examine the neural correlates of lapses.Addiction biology · 2021Article
- Event-related brain response to visual cues in individuals with Internet gaming disorder: relevance to attentional bias and decision-making.Translational psychiatry · 2021Article
- Effects of environmental tobacco smoke exposure on brain functioning in never-smoking adolescents.Brain and behavior · 2020Article
- Habenular and striatal activity during performance feedback are differentially linked with state-like and trait-like aspects of tobacco use disorder.Science advances · 2019Article
- The Effects of Nicotine and Tobacco Use on Brain Reward Function: Interaction With Nicotine Dependence Severity.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2019Article
- Multi-method assessment of distress tolerance and smoking-related factors among adult daily smokers.Experimental and clinical psychopharmacology · 2019Article
- Brain Gray Matter Volume and Functional Connectivity Are Associated With Smoking Cessation Outcomes.Frontiers in human neuroscience · 2019Article
- Gender-related differences in cue-elicited cravings in Internet gaming disorder: The effects of deprivation.Journal of behavioral addictions · 2018Article
- Gender-related differences in neural responses to gaming cues before and after gaming: implications for gender-specific vulnerabilities to Internet gaming disorder.Social cognitive and affective neuroscience · 2018Article
- Functional Neurocircuits and Neuroimaging Biomarkers of Tobacco Use Disorder.Trends in molecular medicine · 2018Review
- Reward-related frontostriatal activity and smoking behavior among adolescents in treatment for smoking cessation.Drug and alcohol dependence · 2017Article
- Momentary Associations Between Reported Craving and Valuing Health in Daily Smokers.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2017Article
- Smoking Abstinence-Induced Changes in Resting State Functional Connectivity with Ventral Striatum Predict Lapse During a Quit Attempt.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2016Article
- The role of dose and restriction state on morphine-, cocaine-, and LiCl-induced suppression of saccharin intake: A comprehensive analysis.Physiology & behavior · 2016Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 1 country.
Funding
Abstract
As a group, cigarette smokers exhibit blunted subjective, behavioral, and neurobiological responses to nondrug incentives and rewards, relative to nonsmokers. Findings from recent studies suggest, however, that there are large individual differences in the devaluation of nondrug rewards among smokers. Moreover, this variability appears to have significant clinical implications, since reduced sensitivity to nondrug rewards is associated with poorer smoking cessation outcomes. Currently, little is known about the neurobiological mechanisms that underlie these individual differences in the responsiveness to nondrug rewards. Here, we tested the hypothesis that individual variability in reward devaluation among smokers is linked to the functioning of the striatum. Specifically, functional magnetic resonance imaging was used to examine variability in the neural response to monetary outcomes in nicotine-deprived smokers anticipating an opportunity to smoke-circumstances found to heighten the devaluation of nondrug rewards by smokers in prior work. We also investigated whether individual differences in reward-related brain activity in those expecting to have access to cigarettes were associated with the degree to which the same individuals subsequently were willing to resist smoking in order to earn additional money. Our key finding was that deprived smokers who exhibited the weakest response to rewards (i.e., monetary gains) in the ventral striatum were least willing to refrain from smoking for monetary reinforcement. These results provide evidence that outcome-related signals in the ventral striatum serve as a marker for clinically meaningful individual differences in reward-motivated behavior among nicotine-deprived smokers.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.