ArticlePlant physiology2014
Genome-Wide Analysis of Heat-Sensitive Alternative Splicing in Physcomitrella patens.
Article in Plant physiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 77 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
77 citing papers in PubMed, 131 citations in OpenAlex.
- Thermotolerance elicits specific genes in cucurbit plants as a response to the combined effect of viral infection and temperature stress.Journal of experimental botany · 2025Article
- A plant-specific clade of serine/arginine-rich proteins regulates RNA splicing homeostasis and thermotolerance in tomato.Nucleic acids research · 2024Article
- Redox Regulation by Priming Agents Toward a Sustainable Agriculture.Plant & cell physiology · 2024Review
- Application of genome editing techniques to regulate gene expression in crops.BMC plant biology · 2024Review
- Responsive Alternative Splicing Events ofInternational journal of molecular sciences · 2024Article
- Article
- The Landscapes of Gluten Regulatory Network in Elite Wheat Cultivars Contrasting in Gluten Strength.International journal of molecular sciences · 2023Article
- The pattern of alternative splicing and DNA methylation alteration and their interaction in linseed (Linum usitatissimum L.) response to repeated drought stresses.Biological research · 2023Article
- Alternative Splicing ofInternational journal of molecular sciences · 2023Article
- Comprehensive profiling of alternative splicing landscape during secondary dormancy in oilseed rape (Molecular breeding : new strategies in plant improvement · 2022Article
- The intersection between circadian and heat-responsive regulatory networks controls plant responses to increasing temperatures.Biochemical Society transactions · 2022Review
- Article
- RNA-seq Analysis Reveals Alternative Splicing Under Heat Stress in Rainbow Trout (Oncorhynchus mykiss).Marine biotechnology (New York, N.Y.) · 2022Article
- Structural analysis of temperature-dependent alternative splicing of HsfA2 pre-mRNA from tomato plants.RNA biology · 2022Article
- Differential alternative splicing genes and isoform co-expression networks ofFrontiers in plant science · 2022Article
- Dynamic changes in the transcriptome landscape ofFrontiers in plant science · 2022Article
- Post-transcriptional regulation of 2-acetyl-1-pyrroline (2-AP) biosynthesis pathway, silicon, and heavy metal transporters in response to Zn in fragrant rice.Frontiers in plant science · 2022Article
- Transcriptome Analysis Explored the Differential Genes' Expression During the Development of theFrontiers in genetics · 2022Article
- Relevance and Regulation of Alternative Splicing in Plant Heat Stress Response: Current Understanding and Future Directions.Frontiers in plant science · 2022Review
- Genetic and Physiological Responses to Heat Stress inFrontiers in plant science · 2022Review
17 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Plant growth and development are constantly influenced by temperature fluctuations. To respond to temperature changes, different levels of gene regulation are modulated in the cell. Alternative splicing (AS) is a widespread mechanism increasing transcriptome complexity and proteome diversity. Although genome-wide studies have revealed complex AS patterns in plants, whether AS impacts the stress defense of plants is not known. We used heat shock (HS) treatments at nondamaging temperature and messenger RNA sequencing to obtain HS transcriptomes in the moss Physcomitrella patens. Data analysis identified a significant number of novel AS events in the moss protonema. Nearly 50% of genes are alternatively spliced. Intron retention (IR) is markedly repressed under elevated temperature but alternative donor/acceptor site and exon skipping are mainly induced, indicating differential regulation of AS in response to heat stress. Transcripts undergoing heat-sensitive IR are mostly involved in specific functions, which suggests that plants regulate AS with transcript specificity under elevated temperature. An exonic GAG-repeat motif in these IR regions may function as a regulatory cis-element in heat-mediated AS regulation. A conserved AS pattern for HS transcription factors in P. patens and Arabidopsis (Arabidopsis thaliana) reveals that heat regulation for AS evolved early during land colonization of green plants. Our results support that AS of specific genes, including key HS regulators, is fine-tuned under elevated temperature to modulate gene regulation and reorganize metabolic processes.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.