ArticleNeuroradiology2014
Neuroimaging diagnosis of pineal region tumors-quest for pathognomonic finding of germinoma.
Article in Neuroradiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 64 citations in OpenAlex.
- Pineal parenchymal tumor of intermediate differentiation: a systematic review and contemporary management of 389 cases reported during the last two decades.Neurosurgical review · 2022Pooled it
- Intracranial Germ Cell Tumors: An Updated Review of Diagnostic Strategies and Treatment Paradigms.Asian journal of neurosurgery · 2026Review
- Multimodal clinical-radiomic-deep learning model for preoperative classification of pediatric pineal region tumors.Neuroradiology · 2026Article
- Multimodal clinical-radiomic-deep learning model for preoperative classification of pediatric pineal region tumors.Neuroradiology · 2026Article
- Imaging of Pineal Region Masses.Advances and technical standards in neurosurgery · 2026Review
- Conclusions.Advances and technical standards in neurosurgery · 2026Review
- Exploration of the cytotoxic and microtubule disruption potential of novel imidazo[1,5-RSC medicinal chemistry · 2025Article
- Update on MRI in pediatric intracranial germ cell tumors-The clinical and radiological features.Frontiers in pediatrics · 2023Review
- Pediatric Pineal Region Tumors: Special Reference to Posterior Interhemispheric Trans-Tentorial Approach.Advances and technical standards in neurosurgery · 2023Review
- Pediatric Pineal Region Tumors: Special Reference to Posterior Interhemispheric Trans-Tentorial Approach.Advances and technical standards in neurosurgery · 2023Review
- Mission impossible: chemotherapy in the intensive care for pineal region germ cell tumor.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2022Article
- Molecular Pathology and Targeted Therapies for Personalized Management of Central Nervous System Germinoma.Journal of personalized medicine · 2021Review
- Pineal region tumors: a complement with imaging nuances.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2021Article
- Pineal Gland Tumors: A Review.Cancers · 2021Review
- Freiburg Neuropathology Case Conference: : Blurred Vision and Headaches in a 15-year-old Boy.Clinical neuroradiology · 2020Article
- Pineal Dysgerminoma: A Misleading Clinical Course With Potential Life-Threatening Consequences.Cureus · 2020Article
- Identification of characteristic features of pineal germinoma that enhance accuracy of preoperative differentiation in pineal region tumors: its significance on optimum surgical treatment.Neurosurgical review · 2018Article
- T2*-based MR imaging (gradient echo or susceptibility-weighted imaging) in midline and off-midline intracranial germ cell tumors: a pilot study.Neuroradiology · 2018Article
- MRI features of pediatric intracranial germ cell tumor subtypes.Journal of neuro-oncology · 2017Article
- Diagnostic accuracy of susceptibility-weighted magnetic resonance imaging for the evaluation of pineal gland calcification.PloS one · 2017Article
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Authors and funding
14 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionOur study aimed to elucidate the imaging features for the differentiation of pineal germinoma and other pineal region tumors.
methodsImage data sets of computed tomographic (CT) scan and magnetic resonance imaging (MRI) data of 93 pineal region tumors including 33 germinomas, 30 nongerminomatous germ cell tumors (NGGCTs), 20 pineal parenchymal tumors (PPTs), and 10 miscellaneous tumors of pineal region were reviewed. Imaging features on CT and MRI were qualitatively assessed by three readers. To know the reasons for morphological differences between germinomas and NGGCTs, histological investigation was done.
resultsLocalized calcification was seen in more than 70 % of germ cells tumors (GCTs: germinomas and NGGCTs) while it was scattered in more than half of PPTs. Cystic components in tumors were most frequent in NGGCTs (62 %). Multiplicity of lesion was restricted to GCTs: 39.4 % in germinoma and 10.0 % in NGGCTs. Thick peritumoral edema was more frequent in germinoma than in NGGCT: 40.6 vs. 14.8 % (p=0.0433, Fisher's test). Bithalamic extension of tumor was seen in 78.8 % of germinomas. It was significantly rare in other groups of tumors (p<0.0001, Fisher's test). The relative collagen amount per unit area was significantly lower in germinoma than in NGGCTs.
conclusionBy paying attention to characteristic features as bithalamic extension, thick peritumoral edema, calcification pattern, multiplicity, and their combination, the preoperative differential diagnosis of pineal germinoma will become more accurate.
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