Evidence map›Paper›PMID 24777251›Full record

ArticleCell research2014

'Lnc'-ing enhancers to MYC regulation.

Scott T Younger, John L Rinn

Open access · bronzeAbstract readComment
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
0.7field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 30 citations in OpenAlex.

  1. LncRNA-Histone Modification Crosstalk: Orchestrating Cancer Pathobiology.Naunyn-Schmiedeberg's archives of pharmacology · 2025
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  16. CRISPR/Cas9 Knockout Strategies to AblateBiological procedures online · 2018
    Article
  17. Review
  18. Oncotarget · 2017
    Article
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  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Scott T Younger1] Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA [2] Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
John L Rinn1] Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA [2] Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA [3] Beth Israel Deaconess Medical Center, Boston, MA 02215, USA.
Beth Israel Deaconess Medical Center · USHarvard University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Long noncoding RNAs (lncRNAs) are emerging as important functional components in the establishment of long-range chromosomal interactions. In a recent paper published in Cell Research, Xiang et al. provide mechanistic insight into this phenomenon by characterizing the role of CCAT1-L, a colorectal cancer-specific lncRNA, in intra-chromosome looping between the MYC gene promoter and distal upstream enhancer elements that regulate MYC transcription.

Indexed as

Gene Expression Regulation, NeoplasticChromatinColorectal NeoplasmsHumansProto-Oncogene Proteins c-mycRNA, Long NoncodingChromatinProto-Oncogene Proteins c-mycRNA, Long Noncoding

Identifiers

PMID24777251
PMCPMC4042177
OpenAlexW1993851018

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.