ArticleVirchows Archiv : an international journal of pathology2014
Thyroglossal duct cyst cancer most likely arises from a thyroid gland remnant.
Article in Virchows Archiv : an international journal of pathology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 33 citations in OpenAlex.
- Thyroglossal duct cyst carcinomas - a retrospective study and systematic review of the literature.Virchows Archiv : an international journal of pathology · 2025Pooled it
- Article
- Papillary Carcinoma Arising From Thyroglossal Duct Cysts: A Case Series and Management Strategies.Cureus · 2025Article
- Carcinoma arising from thyroglossal duct remnants.Biomedical reports · 2024Article
- Malignant degeneration of thyroglossal duct cysts: Clinical aspects, imaging findings and management: Case series.International journal of surgery case reports · 2024Article
- Papillary Thyroid Carcinoma Arising from Thyroglossal Cyst-an Institutional Experience over a Decade.Indian journal of surgical oncology · 2023Article
- Synchronous carcinoma of thyroglossal duct cyst and native thyroid gland.BMJ case reports · 2022Article
- Update from the 5th Edition of the World Health Organization Classification of Head and Neck Tumors: The Neck and Lymph Nodes, Metastasis, and Melanocytic Tumors.Head and neck pathology · 2022Review
- Ectopic thyroid with benign and malignant findings: A case series.International journal of surgery case reports · 2020Article
- BRAFUpdates in surgery · 2019Article
- [Definition of R1 resection in thyroid carcinoma].Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen · 2017Review
- The extent of surgery in thyroglossal cyst carcinoma.Langenbeck's archives of surgery · 2017Article
- Thyroglossal Duct Cyst Carcinomas: A Clinicopathologic Series of 22 Cases with Staging Recommendations.Head and neck pathology · 2017Article
- Imaging characteristics and findings in thyroglossal duct cyst cancer and concurrent thyroid cancer.BMJ case reports · 2016Article
- Thyroglossal duct cyst carcinoma: diagnostic and management considerations in a 15-year-old with a large submental mass.BMJ case reports · 2015Article
- Tall cell carcinoma arising in a thyroglossal duct cyst: A case report.Annals of medicine and surgery (2012) · 2015Article
- Pathology of thyroglossal duct: an institutional experience.Endocrine pathology · 2015Article
- Mucoepidermoid carcinoma in a thyroglossal duct remnant.International journal of surgery case reports · 2015Article
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Authors and funding
10 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Thyroglossal duct cancer is a rare entity, occurring in 1.5 % of all thyroglossal duct cysts (TDC). A definitive consensus about its neoplastic origin has not been established as two contrasting theories exist, one proposing an origin in extra-thyroid remnants and the other a metastatic localization of a primary thyroid cancer. We compare morphological and molecular characteristics of both thyroglossal and thyroid carcinomas in a case series from our institute. We evaluated histology of 80 TDC. In 12 cases, prior cytological evaluation had been performed by liquid-based cytology (LBC). The BRAF gene was examined for mutations, and the histology of both thyroglossal duct and synchronous thyroid carcinoma was reevaluated. In 9 out of 80 (11 %) TDC cases, a papillary thyroid cancer (PTC) was diagnosed. In five out of nine (56 %) thyroglossal carcinomas, a synchronous thyroid cancer was diagnosed: 3 PTC and 2 follicular variant PTC (FVPC). In five thyroglossal carcinomas, mutated BRAF (V600E) was found, three in PTC and in thyroglossal as well as in the synchronous tumor in the thyroid. All the patients are in a disease-free status and still alive. Our results suggest that the majority of thyroglossal carcinomas most likely develop as a primary malignancy from a thyroid remnant. Neither the presence of V600E BRAF mutations nor that of a well-differentiated thyroid carcinoma changed the outcome or disease-free survival. We suggest that a diagnosis of thyroglossal carcinoma should be followed by a detailed evaluation of the thyroid gland. In the absence of clinical and radiological thyroid alterations, follow-up as for thyroid cancer is the correct management.
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