ArticleJournal of child neurology2015
Induced gamma oscillations differentiate familiar and novel voices in children with MECP2 duplication and Rett syndromes.
Article in Journal of child neurology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03077308 (Rett Syndrome, MECP2 Duplication, and Rett-Related Disorders Consortium, Rare Disease Clinical Research Network), which is not on this map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Rett Syndrome, MECP2 Duplication, and Rett-Related Disorders Consortium, Rare Disease Clinical Research Network: Neurophysiologic Correlates
Who cites it
17 citing papers in PubMed, 26 citations in OpenAlex.
- Multidimensional Analysis of a Social Behavior Identifies Regression and Phenotypic Heterogeneity in a Female Mouse Model for Rett Syndrome.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Wild-type MECP2 expression coincides with age-dependent sensory phenotypes in a female mouse model for Rett syndrome.Journal of neuroscience research · 2023Article
- Comparison of evoked potentials across four related developmental encephalopathies.Journal of neurodevelopmental disorders · 2023Article
- Electrophysiological Biomarkers in Genetic Epilepsies.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2021Review
- Detection of neurophysiological features in female R255X MeCP2 mutation mice.Neurobiology of disease · 2020Article
- Psychophysiological and Eye-Tracking Markers of Speech and Language Processing in Neurodevelopmental Disorders: New Options for Difficult-to-Test Populations.American journal on intellectual and developmental disabilities · 2020Review
- Review
- Developmental loss of MeCP2 from VIP interneurons impairs cortical function and behavior.eLife · 2020Article
- Evoked Potentials and EEG Analysis in Rett Syndrome and Related Developmental Encephalopathies: Towards a Biomarker for Translational Research.Frontiers in integrative neuroscience · 2020Article
- Auditory sensory memory span for duration is severely curtailed in females with Rett syndrome.Translational psychiatry · 2019Article
- Spoken word processing in Rett syndrome: Evidence from event-related potentials.International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience · 2019Article
- Social-emotional processing in nonverbal individuals with Angelman syndrome: evidence from brain responses to known and novel names.Journal of intellectual disability research : JIDR · 2019Article
- Feasibility of using auditory event-related potentials to investigate learning and memory in nonverbal individuals with Angelman syndrome.Brain and cognition · 2018Article
- Toward the Language Oscillogenome.Frontiers in psychology · 2018Article
- MECP2 regulates cortical plasticity underlying a learned behaviour in adult female mice.Nature communications · 2017Article
- Automatic cortical representation of auditory pitch changes in Rett syndrome.Journal of neurodevelopmental disorders · 2016Article
- Degraded neural and behavioral processing of speech sounds in a rat model of Rett syndrome.Neurobiology of disease · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Normal levels of the methyl CpG-binding protein 2 (MeCP2) are critical to neurologic functioning, and slight alterations result in intellectual disability and autistic features. It was hypothesized that children with MECP2 duplication (overexpression of MeCP2) and Rett syndrome (underexpression of MeCP2) would exhibit distinct electroencephalographic (EEG) indices of auditory stimulus discrimination. In this study, gamma-band oscillatory responses to familiar and novel voices were examined and related to social functioning in 17 children (3-11 years old) with MECP2 duplication (n = 12) and Rett syndrome (n = 5). Relative to the stranger's voice, gamma activity in response to the mother's voice was increased in MECP2 duplication but decreased in Rett syndrome. In MECP2 duplication, greater mother versus stranger differences in gamma activity were associated with higher social functioning. For the first time, brain responses in a passive voice discrimination paradigm show that overexpression and underexpression of MeCP2 have differential effects on cortical information processing.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.