ArticleMolecular psychiatry2015
Multimodal imaging of a tescalcin (TESC)-regulating polymorphism (rs7294919)-specific effects on hippocampal gray matter structure.
Article in Molecular psychiatry, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 47 citations in OpenAlex.
- Conformational regulation and target-myristoyl switch of calcineurin B homologous protein 3.eLife · 2023Article
- FKBP51 modulates hippocampal size and function in post-translational regulation of Parkin.Cellular and molecular life sciences : CMLS · 2022Article
- ENIGMA-anxiety working group: Rationale for and organization of large-scale neuroimaging studies of anxiety disorders.Human brain mapping · 2022Review
- Cortical surface area alterations shaped by genetic load for neuroticism.Molecular psychiatry · 2020Article
- Biological sex classification with structural MRI data shows increased misclassification in transgender women.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2020Article
- Tescalcin is an unfavorable prognosis factor that regulats cell proliferation and survival in hepatocellular carcinoma patients.Cancer communications (London, England) · 2020Article
- Evidence for a sex-specific contribution of polygenic load for anorexia nervosa to body weight and prefrontal brain structure in nonclinical individuals.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2019Article
- Reduced fractional anisotropy in depressed patients due to childhood maltreatment rather than diagnosis.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2019Article
- Large-scale evidence for an association between low-grade peripheral inflammation and brain structural alterations in major depression in the BiDirect studyJournal of psychiatry & neuroscience : JPN · 2019Article
- Genome-wide association analysis of hippocampal volume identifies enrichment of neurogenesis-related pathways.Scientific reports · 2019Article
- Apolipoprotein E Homozygous ε4 Allele Status: A Deteriorating Effect on Visuospatial Working Memory and Global Brain Structure.Frontiers in neurology · 2019Article
- The Limbic System in Youth Depression: Brain Structural and Functional Alterations in Adolescent In-patients with Severe Depression.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2018Article
- Prefrontal brain responsiveness to negative stimuli distinguishes familial risk for major depression from acute disorder.Journal of psychiatry & neuroscience : JPN · 2017Article
- Imaging Genetics and Genomics in Psychiatry: A Critical Review of Progress and Potential.Biological psychiatry · 2017Review
- Prefrontal gray matter volume mediates genetic risks for obesity.Molecular psychiatry · 2017Article
- Emerging roles of the single EF-hand Ca2+ sensor tescalcin in the regulation of gene expression, cell growth and differentiation.Journal of cell science · 2016Review
- Longitudinal Evidence for Smaller Hippocampus Volume as a Vulnerability Factor for Perceived Stress.Cerebral cortex (New York, N.Y. : 1991) · 2016Article
- Reward Processing in Unipolar and Bipolar Depression: A Functional MRI Study.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2015Article
- NCAN Cross-Disorder Risk Variant Is Associated With Limbic Gray Matter Deficits in Healthy Subjects and Major Depression.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2015Article
- Enhanced neural responsiveness to reward associated with obesity in the absence of food-related stimuli.Human brain mapping · 2015Article
Corrections and comments
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Authors and funding
24 authors at 7 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In two large genome-wide association studies, an intergenic single-nucleotide polymorphism (SNP; rs7294919) involved in TESC gene regulation has been associated with hippocampus volume. Further characterization of neurobiological effects of the TESC gene is warranted using multimodal brain-wide structural and functional imaging. Voxel-based morphometry (VBM8) was used in two large, well-characterized samples of healthy individuals of West-European ancestry (Münster sample, N=503; SHIP-TREND, N=721) to analyze associations between rs7294919 and local gray matter volume. In subsamples, white matter fiber structure was investigated using diffusion tensor imaging (DTI) and limbic responsiveness was measured by means of functional magnetic resonance imaging (fMRI) during facial emotion processing (N=220 and N=264, respectively). Furthermore, gene x environment (G × E) interaction and gene x gene interaction with SNPs from genes previously found to be associated with hippocampal size (FKBP5, Reelin, IL-6, TNF-α, BDNF and 5-HTTLPR/rs25531) were explored. We demonstrated highly significant effects of rs7294919 on hippocampal gray matter volumes in both samples. In whole-brain analyses, no other brain areas except the hippocampal formation and adjacent temporal structures were associated with rs7294919. There were no genotype effects on DTI and fMRI results, including functional connectivity measures. No G × E interaction with childhood maltreatment was found in both samples. However, an interaction between rs7294919 and rs2299403 in the Reelin gene was found that withstood correction for multiple comparisons. We conclude that rs7294919 exerts highly robust and regionally specific effects on hippocampal gray matter structures, but not on other neuropsychiatrically relevant imaging markers. The biological interaction between TESC and RELN pointing to a neurodevelopmental origin of the observed findings warrants further mechanistic investigations.
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