ArticleInternational journal of environmental research and public health2014
Biofilm formation and antimicrobial susceptibility of Staphylococcus epidermidis strains from a hospital environment.
Article in International journal of environmental research and public health, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 73 citations in OpenAlex.
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- Biofilm producing and antibiotic resistant coagulase negative staphylococci in clinical samples isolated from tertiary care hospital of Nepal.Scientific reports · 2026Article
- Influence of sub-inhibitory concentrations of antiseptics on biofilm formation in S. epidermidis.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2025Article
- Coagulase-Negative Staphylococci Determined as Blood Culture Contamination Have High Virulence Characteristic Including Transfer of Antibiotic Resistance Determinants toInternational journal of molecular sciences · 2025Article
- Formulation and characterization of BBR loaded niosomes using saponin as a nonionic biosurfactant investigating synergistic effects to enhance antibacterial activity.Scientific reports · 2025Article
- Evaluation of the Antibacterial Activity of Cinnamic Acid and Its Derivatives: Synergistic Effects with Cloxacillin.Molecules (Basel, Switzerland) · 2025Article
- Article
- Improving Activity of New Arylurea Agents against Multidrug-Resistant and Biofilm-ProducingACS medicinal chemistry letters · 2024Article
- Decreased susceptibility to vancomycin and other mechanisms of resistance to antibiotics in Staphylococcus epidermidis as a therapeutic problem in hospital treatment.Scientific reports · 2023Article
- Insulin Can Delay Neutrophil Extracellular Trap Formation In Vitro-Implication for Diabetic Wound Care?Biology · 2023Article
- Exploring the Biofilm Formation Capacity inPathogens (Basel, Switzerland) · 2022Article
- Epidemiology of Staphylococcus pseudintermedius in cats in Poland.Scientific reports · 2021Article
- Evaluation of Biofilm Formation and Prevalence of Multidrug-Resistant Strains ofPathogens (Basel, Switzerland) · 2021Article
- Phenotypic and genotypic characterization of biofilm producing clinical coagulase negative staphylococci from Nepal and their antibiotic susceptibility pattern.Annals of clinical microbiology and antimicrobials · 2021Article
- Presence ofFrontiers in cellular and infection microbiology · 2021Article
- The Antibacterial Effect of Silver Nanoparticles on Staphylococcus epidermidis Strains with Different Biofilm-Forming Ability.Nanomaterials (Basel, Switzerland) · 2020Article
- Blood culture contamination in a tertiary care hospital of Saudi Arabia. A one-year study.Saudi medical journal · 2020Article
- Safety Evaluation of Individual Pillboxes to Control Cross-Contamination in the Drug Circuit in Hospitals.International journal of environmental research and public health · 2019Article
- Challenges of intervention, treatment, and antibiotic resistance of biofilm-forming microorganisms.Heliyon · 2019Review
- Transcriptional Regulation ofJournal of bacteriology · 2019Article
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The hospital environment microflora comprise a wide variety of microorganisms which are more or less pathogenic and where staphylococci are one of the most common types. The aim of the presented study was to evaluate the prevalence of the biofilm forming coagulase-negative staphylococci (CoNS) in a hospital environment as a risk factor for nosocomial infections. Among 122 isolated and tested strains of CoNS the most frequent were: S. epidermidis-32 strains, S. haemolyticus-31 strains, S. capitis subsp. capitis- 21 strains, S. hominis-11 strains, S. cohnii subsp. cohnii-nine strains. In case of CoNS, the main molecule responsible for intercellular adhesion is a polysaccharide intercellular adhesin (PIA), encoded on the ica gene operon. The analysis revealed the presence of the icaADBC operon genes in 46.88% of S. epidermidis isolates. IcaA and icaD were present in 34.38% and 28.13% of strains respectively while IcaC gene was present in 37.50% of strains. IcaB gene was found in 21.88% of S. epidermidis strains. In 15 (63%) strains all icaADBC operon genes were observed. The assessment of antibacterial drugs susceptibility demonstrated that analyzed CoNS strains were highly resistant to macrolides and lincosamides and more sensitive to rifampicin and linezolid. Our data indicates that the hospital environment can be colonized by biofilm forming coagulase-negative staphylococci and transmission of these strains can cause an increased risk of serious nosocomial infections.
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