Evidence map›Paper›PMID 24776649›Full record

ArticleNature nanotechnology2014

Nanophotonic trapping for precise manipulation of biomolecular arrays.

Mohammad Soltani, Jun Lin, Robert A Forties, James T Inman, Summer N Saraf, Robert M Fulbright, Michal Lipson, Michelle D Wang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature nanotechnology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.

0numbers the graph read from it
0cells of the map it votes in
47citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

47 citing papers in PubMed.

  1. Review
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  8. Review
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  15. The toxicity of SiOJournal of environmental health science & engineering · 2021
    Article
  16. Article
  17. Optical tweezers in single-molecule biophysics.Nature reviews. Methods primers · 2021
    Article
  18. Review
  19. Opto-thermoelectric speckle tweezers.Nanophotonics (Berlin, Germany) · 2020
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Mohammad Soltani1] Department of Physics-Laboratory of Atomic and Solid State Physics, Cornell University, Ithaca, New York 14853, USA [2] Howard Hughes Medical Institute, Cornell University, Ithaca, New York 14853, USA [3].
Jun Lin1] Department of Physics-Laboratory of Atomic and Solid State Physics, Cornell University, Ithaca, New York 14853, USA [2] Howard Hughes Medical Institute, Cornell University, Ithaca, New York 14853, USA [3].
Robert A Forties1] Department of Physics-Laboratory of Atomic and Solid State Physics, Cornell University, Ithaca, New York 14853, USA [2] Howard Hughes Medical Institute, Cornell University, Ithaca, New York 14853, USA.
James T InmanDepartment of Physics-Laboratory of Atomic and Solid State Physics, Cornell University, Ithaca, New York 14853, USA.
Summer N SarafDepartment of Physics-Laboratory of Atomic and Solid State Physics, Cornell University, Ithaca, New York 14853, USA.
Robert M FulbrightDepartment of Physics-Laboratory of Atomic and Solid State Physics, Cornell University, Ithaca, New York 14853, USA.
Michal Lipson1] Department of Electrical and Computer Engineering, Cornell University, Ithaca, New York 14853, USA [2] Kavli Institute at Cornell University, Ithaca, New York 14853, USA.
Michelle D Wang1] Department of Physics-Laboratory of Atomic and Solid State Physics, Cornell University, Ithaca, New York 14853, USA [2] Howard Hughes Medical Institute, Cornell University, Ithaca, New York 14853, USA.

Funding

TRAINING IN MOLECULAR PHYSICS OF BIOLOGICAL SYSTEMST32GM008267 · NIGMS · CORNELL UNIVERSITY ITHACA · PI WANG, MICHELLE D. · 1988 to 2021
$9.6M
STUDIES OF NUCLEOSOME STABILITY AND TRANSCRIPTIONR01GM059849 · NIGMS · CORNELL UNIVERSITY ITHACA · PI WANG, MICHELLE D. · 1999 to 2008
$2.2M
Howard Hughes Medical InstituteNIGMS NIH HHS GM059849NIGMS NIH HHS R01 GM059849NIGMS NIH HHS T32 GM008267NIGMS NIH HHS T32GM008267
6 · The paper itself

Abstract

Optical trapping is a powerful manipulation and measurement technique widely used in the biological and materials sciences. Miniaturizing optical trap instruments onto optofluidic platforms holds promise for high-throughput lab-on-a-chip applications. However, a persistent challenge with existing optofluidic devices has been achieving controlled and precise manipulation of trapped particles. Here, we report a new class of on-chip optical trapping devices. Using photonic interference functionalities, an array of stable, three-dimensional on-chip optical traps is formed at the antinodes of a standing-wave evanescent field on a nanophotonic waveguide. By employing the thermo-optic effect via integrated electric microheaters, the traps can be repositioned at high speed (∼30 kHz) with nanometre precision. We demonstrate sorting and manipulation of individual DNA molecules. In conjunction with laminar flows and fluorescence, we also show precise control of the chemical environment of a sample with simultaneous monitoring. Such a controllable trapping device has the potential to achieve high-throughput precision measurements on chip.

Indexed as

Lab-On-A-Chip DevicesOptical TweezersOligonucleotide Array Sequence Analysis

Identifiers

PMID24776649
PMCPMC4047199

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.