Evidence map›Paper›PMID 24776634›Full record

ArticleNature methods2014

Chronic, wireless recordings of large-scale brain activity in freely moving rhesus monkeys.

David A Schwarz, Mikhail A Lebedev, Timothy L Hanson, Dragan F Dimitrov, Gary Lehew, Jim Meloy, Sankaranarayani Rajangam, Vivek Subramanian, Peter J Ifft, Zheng Li and 4 more

Registry-linked trialOpen access · greenAbstract read
In one paragraph

Article in Nature methods, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03811301 (Neurodevice Phase I), which is not on this map. Cited by 137 papers.

0numbers the graph read from it
0cells of the map it votes in
137citing papers in PubMed
18.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03811301 naunknown statusnot on this mapstarted 2017, after this paper: background citation

Neurodevice Phase I: Wireless Implantable Neurodevice Microsystem for Neuroprosthesis and Neuroscience

TypeinterventionalSponsorNational Neuroscience InstituteRan2017 to 2023Enrolled5ConditionsTetraplegia, Tetraplegia/Tetraparesis, Spinal Cord Injuries, Amyotrophic Lateral SclerosisArmsBrainConnexion
3 · Its place in the literature

Who cites it

137 citing papers in PubMed, 366 citations in OpenAlex.

  1. Article
  2. Primate neuroethology: a new synthesis.Trends in cognitive sciences · 2026
    Review
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77 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 2 institutions in 1 country.

David A Schwarz1] Department of Neurobiology, Duke University, Durham, North Carolina, USA. [2] Center for Neuroengineering, Duke University, Durham, North Carolina, USA.
Mikhail A Lebedev1] Department of Neurobiology, Duke University, Durham, North Carolina, USA. [2] Center for Neuroengineering, Duke University, Durham, North Carolina, USA.
Timothy L Hanson1] Department of Neurobiology, Duke University, Durham, North Carolina, USA. [2] Center for Neuroengineering, Duke University, Durham, North Carolina, USA.
Dragan F DimitrovMonterey Spine, Monterey, California, USA.
Gary Lehew1] Department of Neurobiology, Duke University, Durham, North Carolina, USA. [2] Center for Neuroengineering, Duke University, Durham, North Carolina, USA.
Jim Meloy1] Department of Neurobiology, Duke University, Durham, North Carolina, USA. [2] Center for Neuroengineering, Duke University, Durham, North Carolina, USA.
Sankaranarayani Rajangam1] Department of Neurobiology, Duke University, Durham, North Carolina, USA. [2] Center for Neuroengineering, Duke University, Durham, North Carolina, USA.
Vivek Subramanian1] Center for Neuroengineering, Duke University, Durham, North Carolina, USA. [2] Department of Biomedical Engineering, Duke University, Durham, North Carolina, USA.
Peter J Ifft1] Center for Neuroengineering, Duke University, Durham, North Carolina, USA. [2] Department of Biomedical Engineering, Duke University, Durham, North Carolina, USA.
Zheng Li1] Department of Neurobiology, Duke University, Durham, North Carolina, USA. [2] Center for Neuroengineering, Duke University, Durham, North Carolina, USA.
Arjun Ramakrishnan1] Department of Neurobiology, Duke University, Durham, North Carolina, USA. [2] Center for Neuroengineering, Duke University, Durham, North Carolina, USA.
Andrew Tate1] Department of Neurobiology, Duke University, Durham, North Carolina, USA. [2] Center for Neuroengineering, Duke University, Durham, North Carolina, USA.
Katie Z Zhuang1] Center for Neuroengineering, Duke University, Durham, North Carolina, USA. [2] Department of Biomedical Engineering, Duke University, Durham, North Carolina, USA.
Miguel A L Nicolelis1] Department of Neurobiology, Duke University, Durham, North Carolina, USA. [2] Center for Neuroengineering, Duke University, Durham, North Carolina, USA. [3] Department of Biomedical Engineering, Duke University, Durham, North Carolina, USA. [4] Department of Psychology and Neuroscience, Duke University, Durham, North Carolina, USA. [5] Edmond and Lily Safra International Institute of Neuroscience of Natal, Natal, Brazil.
Duke University · USMonterey Technologies (United States) · US

Funding

Duke CTSA (Composite)UL1TR001117 · NCATS · DUKE UNIVERSITY · PI BOULWARE, LEIGH E, LI, JENNIFER S · 2013 to 2017
$41.3M
Basic Predoctoral Training in NeuroscienceT32GM008441 · NIGMS · DUKE UNIVERSITY · PI MCNAMARA, JAMES O. · 1992 to 2017
$4.4M
Interval Timing and Motor Programming by Cortico-Striatal EnsemblesR01NS073952 · NINDS · DUKE UNIVERSITY · PI NICOLELIS, MIGUEL A. L. · 2011 to 2015
$2.5M
A Virtual Reality Simulator to Study VLSBA and Test Brain-Actuating TechnologiesDP1MH099903 · NIMH · DUKE UNIVERSITY · PI NICOLELIS, MIGUEL A. L. · 2012 to 2014
$2.3M
A Virtual Reality Simulator to Study VLSBA and Test Brain-Actuating TechnologiesDP1OD006798 · OD · DUKE UNIVERSITY · PI NICOLELIS, MIGUEL A. L. · 2010 to 2011
$1.6M
NCATS NIH HHS UL1 TR001117NCCDPHP CDC HHS DP1MH099903NIGMS NIH HHS T32 GM008441NIH HHS DP1 OD006798NIMH NIH HHS DP1 MH099903NINDS NIH HHS R01 NS073952NINDS NIH HHS R01NS073952
6 · The paper itself

Abstract

Advances in techniques for recording large-scale brain activity contribute to both the elucidation of neurophysiological principles and the development of brain-machine interfaces (BMIs). Here we describe a neurophysiological paradigm for performing tethered and wireless large-scale recordings based on movable volumetric three-dimensional (3D) multielectrode implants. This approach allowed us to isolate up to 1,800 neurons (units) per animal and simultaneously record the extracellular activity of close to 500 cortical neurons, distributed across multiple cortical areas, in freely behaving rhesus monkeys. The method is expandable, in principle, to thousands of simultaneously recorded channels. It also allows increased recording longevity (5 consecutive years) and recording of a broad range of behaviors, such as social interactions, and BMI paradigms in freely moving primates. We propose that wireless large-scale recordings could have a profound impact on basic primate neurophysiology research while providing a framework for the development and testing of clinically relevant neuroprostheses.

Indexed as

Electrodes, ImplantedWireless TechnologyAnimalsBrainElectronic Data ProcessingMacaca mulattaNeurophysiology

Identifiers

PMID24776634
PMCPMC4161037
OpenAlexW2018255768

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.