ArticleCritical care medicine2014
Computed tomography-defined abdominal adiposity is associated with acute kidney injury in critically ill trauma patients*.
Article in Critical care medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 40 citations in OpenAlex.
- A risk-score prediction of postoperative acute kidney injury following lung transplantation: a retrospective cohort study.Journal of cardiothoracic surgery · 2025Article
- Beyond body mass index: exploring the role of visceral adipose tissue in intensive care unit outcomes.BJA open · 2025Review
- Comparison of the predictive value of different non-insulin-based insulin resistance indices for acute kidney injury in patients with sepsis: a retrospective study.Frontiers in endocrinology · 2025Article
- Article
- High Fat-to-Muscle Ratio Was Associated with Increased Clinical Severity in Patients with Abdominal Trauma.Journal of clinical medicine · 2023Article
- Subcutaneous Adipose Tissue Is Associated with Acute Kidney Injury after Abdominal Trauma Based on the Generalized Propensity Score Approach: A Retrospective Cohort Study.Obesity facts · 2023Article
- The Impact of Myosteatosis Percentage on Short-Term Mortality in Patients with Septic Shock.Journal of clinical medicine · 2022Article
- Adipose tissue: a neglected organ in the response to severe trauma?Cellular and molecular life sciences : CMLS · 2022Review
- Volumetric Markers of Body Composition May Improve Personalized Prediction of Major Arterial Bleeding After Pelvic Fracture: A Secondary Analysis of the Baltimore CT Prediction Model Cohort.Canadian Association of Radiologists journal = Journal l'Association canadienne des radiologistes · 2021Article
- Does a "Cushion Effect" Really Exist? A Morphomic Analysis of Vulnerable Road Users with Serious Blunt Abdominal Injury.Healthcare (Basel, Switzerland) · 2021Article
- Obese trauma patients have increased need for dialysis.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2020Article
- Relationship of body mass index, serum creatine kinase, and acute kidney injury after severe trauma.The journal of trauma and acute care surgery · 2020Article
- Adipose tissue quantification and primary graft dysfunction after lung transplantation: The Lung Transplant Body Composition study.The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation · 2019Article
- The association of post-lung transplant acute kidney injury with mortality is independent of primary graft dysfunction: A cohort study.Clinical transplantation · 2019Article
- Plasma receptor interacting protein kinase-3 levels are associated with acute respiratory distress syndrome in sepsis and trauma: a cohort study.Critical care (London, England) · 2019Article
- Low to Moderate Air Pollutant Exposure and Acute Respiratory Distress Syndrome after Severe Trauma.American journal of respiratory and critical care medicine · 2019Article
- Postoperative acute kidney injury.Korean journal of anesthesiology · 2017Review
- [Above and beyond BMI : Alternative methods of measuring body fat and muscle mass in critically ill patients and their clinical significance].Der Anaesthesist · 2016Review
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11 authors at 2 institutions in 1 country.
Funding
Abstract
objectivesHigher body mass index is associated with increased risk of acute kidney injury after major trauma. Since body mass index is nonspecific, reflecting lean, fluid, and adipose mass, we evaluated the use of CT to determine if abdominal adiposity underlies the body mass index-acute kidney injury association.
designProspective cohort study.
settingLevel I Trauma Center of a university hospital. PATIENTS: Patients older than 13 years with an Injury Severity Score greater than or equal to 16 admitted to the trauma ICU were followed for development of acute kidney injury over 5 days. Those with isolated severe head injury or on chronic dialysis were excluded.
interventionsNone. MEASUREMENTS AND MAIN
resultsClinical, anthropometric, and demographic variables were collected prospectively. CT images at the level of the L4-5 intervertebral disc space were extracted from the medical record and used by two operators to quantitate visceral adipose tissue and subcutaneous adipose tissue areas. Acute kidney injury was defined by Acute Kidney Injury Network creatinine and dialysis criteria. Of 400 subjects, 327 (81.8%) had CT scans suitable for analysis: 264 of 285 (92.6%) blunt trauma subjects and 63 of 115 (54.8%) penetrating trauma subjects. Visceral adipose tissue and subcutaneous adipose tissue areas were highly correlated between operators (intraclass correlation > 0.99, p < 0.001 for each) and within operator (intraclass correlation > 0.99, p < 0.001 for each). In multivariable analysis, the standardized risk of acute kidney injury was 15.1% (95% CI, 10.6-19.6%), 18.1% (14-22.2%), and 23.1% (18.3-27.9%) at the 25th, 50th, and 75th percentiles of visceral adipose tissue area, respectively (p = 0.001), with similar findings when using subcutaneous adipose tissue area as the adiposity measure.
conclusionsQuantitation of abdominal adiposity using CT scans obtained for clinical reasons is feasible and highly reliable in critically ill trauma patients. Abdominal adiposity is independently associated with acute kidney injury in this population, confirming that excess adipose tissue contributes to the body mass index-acute kidney injury association. Further studies of the potential mechanisms linking adiposity with acute kidney injury are warranted.
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