ArticleNicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco2014
Early life exposure to cigarette smoke and depressive symptoms among women in midlife.
Article in Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 5 of them syntheses that pooled it.
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Who cites it
14 citing papers in PubMed, 5 syntheses or guidelines pooled it, 25 citations in OpenAlex.
- The Impact of Maternal Smoking During Pregnancy on Depressive and Anxiety Behaviors in Offspring: A Meta-analysis.Depression and anxiety · 2025Pooled it
- Association between indoor air pollution and depression: a systematic review and meta-analysis of cohort studies.BMJ open · 2024Pooled it
- Research Review: Developmental origins of depression - a systematic review and meta-analysis.Journal of child psychology and psychiatry, and allied disciplines · 2021Pooled it
- Relationship Between Secondhand Smoke Exposure and Depressive Symptoms: A Systematic Review and Dose⁻Response Meta-Analysis.International journal of environmental research and public health · 2019Pooled it
- Secondhand smoke exposure and mental health in adults: a meta-analysis of cross-sectional studies.Social psychiatry and psychiatric epidemiology · 2016Pooled it
- Perinatal nicotine-induced neurotoxicity and behavioral alterations in newborn mice are associated with oxidative stress, inflammation and downregulated Nrf2/HO-1 signaling: protective role of Anethum graveolens.Journal of molecular histology · 2025Article
- A Scoping Review of Non-Occupational Exposures to Environmental Pollutants and Adult Depression, Anxiety, and Suicide.Current environmental health reports · 2020Article
- Prenatal nicotine exposure induces depression‑like behavior in adolescent female rats via modulating neurosteroid in the hippocampus.Molecular medicine reports · 2019Article
- Maternal cigarette smoking during pregnancy and offspring DNA methylation in midlife.Epigenetics · 2018Article
- Smoking and secondhand smoke exposure and prevalence of depressive symptoms during pregnancy in Japan: baseline data from the Kyushu Okinawa Maternal and Child Health Study.Tobacco induced diseases · 2017Article
- Article
- Prenatal and Early Postnatal Exposure to Cigarette Smoke Decreases BDNF/TrkB Signaling and Increases Abnormal Behaviors Later in Life.The international journal of neuropsychopharmacology · 2016Article
- Secondhand smoke exposure and mental health problems in Korean adults.Epidemiology and health · 2016Article
- Article
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
Abstract
introductionActive cigarette smoking has consistently been associated with depression, but little is known about the association between other cigarette smoke exposures, particularly in early life, and depression. We investigated whether exposures to maternal smoking during pregnancy (MSP) and childhood secondhand smoke (SHS) are associated with depressive symptoms in midlife.
methodsPregnant mothers were enrolled and were provided data on maternal smoking and other parental characteristics. Female offspring were followed through age 7 years and again in midlife (age range = 38-44 years), when they provided data on smoking history, SHS across the life course, and current depressive symptoms using the Center for Epidemiological Studies Depression Scale (CES-D).
resultsParticipants exposed to MSP had a higher risk for depression (risk ratio [RR] = 1.83, 95% confidence interval [CI] = 1.08, 3.09) than those without MSP exposure. Relative to those with no MSP and no childhood SHS exposures, participants with MSP and childhood SHS had more than twice the risk of depressive symptoms (RR = 2.40, 95% CI = 1.07, 5.41). Further adjustment for adult factors, particularly current smoking, substantially reduced these associations (e.g., MSP vs. no MSP exposure: RR = 1.36 [95% CI = 0.75, 2.45]).
conclusionsEarly life exposure to cigarette smoke is associated with increased risk for depression in midlife, with the association largely mediated by active smoking. These findings support a role for early life cigarette exposures in shaping smoking and depression risks in later life, and they provide some support for the direction of smoke exposure influence on depression.
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