Evidence map›Paper›PMID 24776325›Full record

Trial reportAmerican journal of kidney diseases : the official journal of the National Kidney Foundation2014

Short-term aerobic exercise and vascular function in CKD stage 3: a randomized controlled trial.

Samuel Headley, Michael Germain, Richard Wood, Jyovani Joubert, Charles Milch, Elizabeth Evans, Anthony Poindexter, Allen Cornelius, Britton Brewer, Linda S Pescatello and 1 more

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in American journal of kidney diseases : the official journal of the National Kidney Foundation, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 67 papers, 20 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
67citing papers in PubMed, 20 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

67 citing papers in PubMed, 20 syntheses or guidelines pooled it.

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7 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Samuel HeadleySpringfield College, Springfield, MA. Electronic address: sheadley@springfieldcollege.edu.
Michael GermainWestern New England Renal & Transplant Associates, Springfield, MA.
Richard WoodSpringfield College, Springfield, MA.
Jyovani JoubertSpringfield College, Springfield, MA.
Charles MilchSpringfield College, Springfield, MA.
Elizabeth EvansSpringfield College, Springfield, MA.
Anthony PoindexterWestern New England Renal & Transplant Associates, Springfield, MA; University of the Rockies, Colorado Springs, CO.
Allen CorneliusUniversity of the Rockies, Colorado Springs, CO.
Britton BrewerSpringfield College, Springfield, MA.
Linda S PescatelloUniversity of Connecticut, Storrs.
Beth ParkerUniversity of Hartford, West Hartford, CT.

Funding

The effect of short-term aerobic training on arterial stiffness and blood pressurR15HL096097 · NHLBI · SPRINGFIELD COLLEGE · PI HEADLEY, SAMUEL A · 2009 to 2012
$377k
NHLBI NIH HHS 1R15HL096097-01NHLBI NIH HHS R15 HL096097
6 · The paper itself

Abstract

backgroundThe present study was designed to determine the effect of short-term moderate-intensity exercise training on arterial stiffness in patients with chronic kidney disease (CKD) stage 3. STUDY

designRandomized controlled trial with a parallel-group design. SETTING &

participantsTesting and training sessions were performed at Springfield College. 46 (treatment group, n=25; control group, n=21) patients with CKD with diabetes and/or hypertension completed the study.

interventionThe aerobic training program consisted of 16 weeks of supervised exercise training at 50%-60% peak oxygen uptake (Vo2peak) 3 times per week, while the control group remained sedentary. Identical testing procedures were performed following the 16-week intervention. OUTCOMES: The primary outcome was arterial stiffness. Secondary outcomes were aerobic capacity, various blood parameters (endothelin 1, nitrate/nitrite, and high-sensitivity C-reactive protein), and health-related quality of life. MEASUREMENTS: Arterial stiffness was assessed with aortic pulse wave velocity (PWV), aerobic capacity by Vo2peak, blood parameters by enzyme-linked immunosorbent assays, and health-related quality of life by the 36-Item Short Form Health Survey (SF-36). Participants attended 4 sessions before being randomly assigned to either the treatment or control group. Participants gave consent during the first session, whereas a graded exercise test with measurement of Vo2peak was completed during the second session. During sessions 3 and 4, aortic PWV was measured at rest prior to 40 minutes of either moderate-intensity exercise training or seated rest. A venous blood sample was obtained prior to exercise or rest and participants completed the SF-36 questionnaire.

results16 weeks of training led to an 8.2% increase in Vo2peak for the treatment group (P=0.05), but no changes in aortic PWV . LIMITATIONS: Randomization was not concealed and was violated on one occasion; also, use of an indirect measurement of endothelial function and the short duration of the intervention.

conclusionsShort-term moderate-intensity exercise training does not alter arterial stiffness in patients with CKD, but seems to reduce endothelin 1 levels.

Indexed as

AdultAgedExerciseFemaleFollow-Up StudiesHumansMaleMiddle AgedRenal Insufficiency, ChronicTime FactorsVascular ResistanceVascular Stiffnessaerobic trainingArterial stiffnesscarotid-femoral arterial stiffnesschronic kidney disease (CKD)endotheliumpulse wave velocityshort-termvascular functionvasoactive balance

Identifiers

PMID24776325
PMCPMC4112010

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.