Evidence map›Paper›PMID 24775306›Full record

ArticleBioorganic & medicinal chemistry letters2014

Antimalarial chemotherapy: artemisinin-derived dimer carbonates and thiocarbonates.

Jennifer R Mazzone, Ryan C Conyers, Abhai K Tripathi, David J Sullivan, Gary H Posner

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioorganic & medicinal chemistry letters, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 17 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Jennifer R MazzoneDepartment of Chemistry, School of Arts and Sciences, The Johns Hopkins University, 3400 North Charles Street, Baltimore, MD 21218, United States.
Ryan C ConyersDepartment of Chemistry, School of Arts and Sciences, The Johns Hopkins University, 3400 North Charles Street, Baltimore, MD 21218, United States.
Abhai K TripathiW. Harry Feinstone Department of Molecular Microbiology and Immunology, Bloomberg School of Public Health, The Johns Hopkins University, Baltimore, MD 21205, United States; The Johns Hopkins Malaria Research Institute, Bloomberg School of Public Health, The Johns Hopkins University, Baltimore, MD 21205, United States.
David J SullivanW. Harry Feinstone Department of Molecular Microbiology and Immunology, Bloomberg School of Public Health, The Johns Hopkins University, Baltimore, MD 21205, United States; The Johns Hopkins Malaria Research Institute, Bloomberg School of Public Health, The Johns Hopkins University, Baltimore, MD 21205, United States.
Gary H PosnerDepartment of Chemistry, School of Arts and Sciences, The Johns Hopkins University, 3400 North Charles Street, Baltimore, MD 21218, United States; The Johns Hopkins Malaria Research Institute, Bloomberg School of Public Health, The Johns Hopkins University, Baltimore, MD 21205, United States. Electronic address: ghp@jhu.edu.
Johns Hopkins University · US

Funding

Peroxides for Chemotherapy of Malaria and CancerR37AI034885 · NIAID · JOHNS HOPKINS UNIVERSITY · PI POSNER, GARY H · 2006 to 2015
$4.3M
NIAID NIH HHS R37 AI034885NIAID NIH HHS R37 AI 34885
6 · The paper itself

Abstract

Several 2-carbon-linked trioxane dimer secondary alcohol carbonates 14 and thiocarbonates 15, combined with mefloquine and administered in a low single oral dose, prolonged the survival times of malaria-infected mice much more effectively than the popular monomeric antimalarial drug artemether plus mefloquine. Three dimer carbonates 14 and one dimer thiocarbonate 15 partially cured malaria-infected mice.

Indexed as

AnimalsAntimalarialsArtemisininsCarbonatesDimerizationDisease Models, AnimalDose-Response Relationship, DrugMalariaMaleMiceMice, Inbred C57BLMolecular StructureParasitic Sensitivity TestsPlasmodium bergheiStructure-Activity RelationshipSulfhydryl CompoundsAntimalarialsartemisininArtemisininsCarbonatesSulfhydryl CompoundsAntimalarial chemotherapyOral bioavailabilitySingle oral dose ACTTrioxane dimers

Identifiers

PMID24775306
PMCPMC4074917
OpenAlexW2051661041

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.