ArticleJournal of the American Society of Echocardiography : official publication of the American Society of Echocardiography2014
Ischemic memory imaging in nonhuman primates with echocardiographic molecular imaging of selectin expression.
Article in Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07762495 (Echocardiographic Molecular Imaging for POC Detection of Ischemia), which is not on this map. Cited by 15 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Echocardiographic Molecular Imaging for POC Detection of Ischemia
Who cites it
15 citing papers in PubMed.
- Echocardiographic Ischemic Memory Molecular Imaging for Point-of-Care Detection of Myocardial Ischemia.Journal of the American College of Cardiology · 2021Trial
- Inflammasome inhibition in myocardial infarction reduces early reperfusion injury and suppresses systemic plaque activation.Atherosclerosis · 2026Article
- Molecular Ultrasound Imaging.Nanomaterials (Basel, Switzerland) · 2020Review
- Ultrasound molecular imaging: insights into cardiovascular pathology.Journal of echocardiography · 2020Review
- Ultrasound Molecular Imaging: Principles and Applications in Cardiovascular Medicine.Current cardiology reports · 2019Review
- Molecular Imaging of the Heart.Comprehensive Physiology · 2019Review
- Accelerated Clearance of Ultrasound Contrast Agents Containing Polyethylene Glycol is Associated with the Generation of Anti-Polyethylene Glycol Antibodies.Ultrasound in medicine & biology · 2018Article
- Sentinel Lymph Node Characterization with a Dual-Targeted Molecular Ultrasound Contrast Agent.Molecular imaging and biology · 2018Article
- Monitoring inflammation injuries in the progression of atherosclerosis with contrast enhanced ultrasound molecular imaging.PloS one · 2017Article
- Echocardiographic Ischemic Memory Imaging Through Complement-Mediated Vascular Adhesion of Phosphatidylserine-Containing Microbubbles.JACC. Cardiovascular imaging · 2016Article
- [Molecular ultrasound imaging: Clinical applications].Der Radiologe · 2015Review
- Requisite Role of Kv1.5 Channels in Coronary Metabolic Dilation.Circulation research · 2015Article
- Ultrasound molecular imaging: Moving toward clinical translation.European journal of radiology · 2015Review
- A Targeting Microbubble for Ultrasound Molecular Imaging.PloS one · 2015Article
- Targeting of microbubbles: contrast agents for ultrasound molecular imaging.Journal of drug targetingReview
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
backgroundSelectins are adhesion molecules that are expressed by the vascular endothelium upon activation and may be an imaging target for detecting myocardial ischemia long after resolution. The aim of this study was to test the hypothesis that molecular imaging of selectins with myocardial contrast echocardiographic (MCE) molecular imaging could be used to detect recent brief ischemia in closed-chest nonhuman primates.
methodsMyocardial ischemia was produced in anesthetized adult rhesus macaques (n = 6) by percutaneous balloon catheter occlusion of the left anterior descending or circumflex coronary artery for 5 to 10 min. Three separate macaques served as nonischemic controls. MCE perfusion imaging was performed during coronary occlusion to measure risk area and at 100 to 110 min to exclude infarction. MCE molecular imaging was performed at 30 and 90 min after reperfusion using a lipid microbubble bearing dimeric recombinant human P-selectin glycoprotein ligand-1 (MB-YSPSL). Collection of blood for safety data, electrocardiography, and echocardiography were performed at baseline and before and 10 min after each MB-YSPSL injection.
resultsVital signs, oxygen saturation, electrocardiographic results, ventricular systolic function, pulmonary vascular resistance, and serum safety markers were unchanged by intravenous injection of MB-YSPSL. On echocardiography, left ventricular dysfunction in the risk area had resolved by 30 min, and there was no evidence of infarction on MCE perfusion imaging. On selectin-targeted MCE molecular imaging, signal enhancement was greater (P < .05) in the risk area than remote territory at 30 min (25 ± 11 vs 11 ± 4 IU) and 90 min (13 ± 3 vs 3 ± 2 IU) after ischemia. There was no enhancement (<1 IU) in control nonischemic subjects.
conclusionsIn primates, MCE molecular imaging of selectins using MB-YSPSL, a recombinant ligand appropriate for humans, is both safe and effective for imaging recent myocardial ischemia. This technique may be useful for detecting recent ischemia in patients with chest pain even in the absence of necrosis.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.